Molecular Mechanisms of Skeletal Muscle Hypertrophy

Stefano Schiaffino, Carlo Reggiani, Takayuki Akimoto, Bert Blaauw

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and by mechanical signals mediating the effect of resistance exercise. Muscle growth during hypertrophy is controlled at the translational level, through the stimulation of protein synthesis, and at the transcriptional level, through the activation of ribosomal RNAs and muscle-specific genes. mTORC1 has a central role in the regulation of both protein synthesis and ribosomal biogenesis. Several transcription factors and co-activators, including MEF2, SRF, PGC-1a4, and YAP promote the growth of the myofibers. Satellite cell proliferation and fusion is involved in some but not all muscle hypertrophy models.

本文言語English
ページ(範囲)169-183
ページ数15
ジャーナルJournal of Neuromuscular Diseases
8
2
DOI
出版ステータスPublished - 2021

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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