Monitoring surface-assisted biomolecular assembly by means of evanescent-field-coupled waveguide-mode nanobiosensors

Subash C.B. Gopinath, Koichi Awazu, Makoto Fujimaki, Katsuaki Sugimoto, Yoshimichi Ohki, Tetsuro Komatsubara, Junji Tominaga, Penmetcha K.R. Kumar

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Biological self-assembly is a natural process that involves various biomolecules, and finding the missing partner in these interactions is crucial for a specific biological function. Previously, we showed that evanescent-field-coupled waveguide-mode sensor in conjunction with a SiO 2 waveguide, the surfaces which contain cylindrical nanometric holes produced by atomic bombardment, allowed us to detect efficiently the biomolecular interactions. In the present studies, we showed that the assembly of biomolecules can be monitored using the evanescent-field-coupled waveguide-mode biosensor and thus provide a methodology in monitoring assembly process in macromolecular machines while they are assembling.

本文言語English
ページ(範囲)481-488
ページ数8
ジャーナルAnalytical and Bioanalytical Chemistry
394
2
DOI
出版ステータスPublished - 2009 5 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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