Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells

Tetsuya Tsuji, Shinji Takeoka, Yosuke Okamura, Ryo Sudo, Yasuo Ikeda, Kazuo Tanishita

    研究成果: Article

    1 引用 (Scopus)

    抄録

    Polymerized albumin particles (poly Alb) with recombinant glycoprotein Ibα (rGPIbα-poly Alb) are a promising candidate for a platelet substitute. Thus, we focused on the lateral motion of poly Alb in the presence of red blood cells, because the lateral motion plays an important role in aggregate formation. We visualized the microscopic motion of poly Alb toward the immobilized ligand (von Willebrand factor, VWF) surface in a model arteriole with red blood cells with a high-speed camera. At a higher shear rate of 1,500 s-1, the concentration profile of poly Alb appeared to peak near the wall. This profile enhances the interaction between the particles and wall. Particularly the migration angle, being the angle of the poly Alb velocity vector, was enlarged near the wall and contributed to transfer of poly Alb toward the immobilized VWF surface. This tendency is desirable to achieve the adhesion of particles on the wall.

    元の言語English
    ページ(範囲)29-34
    ページ数6
    ジャーナルJournal of Biorheology
    23
    発行部数1
    DOI
    出版物ステータスPublished - 2009

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    Albumins
    Blood
    Cells
    Glycoproteins
    High speed cameras
    Platelets
    Shear deformation
    Adhesion
    Ligands
    von Willebrand Factor
    Platelet Glycoprotein GPIb-IX Complex

    ASJC Scopus subject areas

    • Mechanics of Materials
    • Materials Science(all)
    • Mechanical Engineering

    これを引用

    Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells. / Tsuji, Tetsuya; Takeoka, Shinji; Okamura, Yosuke; Sudo, Ryo; Ikeda, Yasuo; Tanishita, Kazuo.

    :: Journal of Biorheology, 巻 23, 番号 1, 2009, p. 29-34.

    研究成果: Article

    Tsuji, Tetsuya ; Takeoka, Shinji ; Okamura, Yosuke ; Sudo, Ryo ; Ikeda, Yasuo ; Tanishita, Kazuo. / Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells. :: Journal of Biorheology. 2009 ; 巻 23, 番号 1. pp. 29-34.
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    abstract = "Polymerized albumin particles (poly Alb) with recombinant glycoprotein Ibα (rGPIbα-poly Alb) are a promising candidate for a platelet substitute. Thus, we focused on the lateral motion of poly Alb in the presence of red blood cells, because the lateral motion plays an important role in aggregate formation. We visualized the microscopic motion of poly Alb toward the immobilized ligand (von Willebrand factor, VWF) surface in a model arteriole with red blood cells with a high-speed camera. At a higher shear rate of 1,500 s-1, the concentration profile of poly Alb appeared to peak near the wall. This profile enhances the interaction between the particles and wall. Particularly the migration angle, being the angle of the poly Alb velocity vector, was enlarged near the wall and contributed to transfer of poly Alb toward the immobilized VWF surface. This tendency is desirable to achieve the adhesion of particles on the wall.",
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    AU - Tsuji, Tetsuya

    AU - Takeoka, Shinji

    AU - Okamura, Yosuke

    AU - Sudo, Ryo

    AU - Ikeda, Yasuo

    AU - Tanishita, Kazuo

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