Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells

Tetsuya Tsuji, Shinji Takeoka, Yosuke Okamura, Ryo Sudo, Yasuo Ikeda, Kazuo Tanishita*

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Polymerized albumin particles (poly Alb) with recombinant glycoprotein Ibα (rGPIbα-poly Alb) are a promising candidate for a platelet substitute. Thus, we focused on the lateral motion of poly Alb in the presence of red blood cells, because the lateral motion plays an important role in aggregate formation. We visualized the microscopic motion of poly Alb toward the immobilized ligand (von Willebrand factor, VWF) surface in a model arteriole with red blood cells with a high-speed camera. At a higher shear rate of 1,500 s-1, the concentration profile of poly Alb appeared to peak near the wall. This profile enhances the interaction between the particles and wall. Particularly the migration angle, being the angle of the poly Alb velocity vector, was enlarged near the wall and contributed to transfer of poly Alb toward the immobilized VWF surface. This tendency is desirable to achieve the adhesion of particles on the wall.

本文言語English
ページ(範囲)29-34
ページ数6
ジャーナルJournal of Biorheology
23
1
DOI
出版ステータスPublished - 2009

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学

フィンガープリント

「Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル