TY - JOUR
T1 - Multiple animal positioning system shows that socially-reared mice influence the social proximity of isolation-reared cagemates
AU - Endo, Nozomi
AU - Ujita, Waka
AU - Fujiwara, Masaya
AU - Miyauchi, Hideaki
AU - Mishima, Hiroyuki
AU - Makino, Yusuke
AU - Hashimoto, Lisa
AU - Oyama, Hiroshi
AU - Makinodan, Manabu
AU - Nishi, Mayumi
AU - Tohyama, Chiharu
AU - Kakeyama, Masaki
N1 - Funding Information:
This study was supported in part by the Strategic Research Program for Brain Sciences (SRPBS) from MEXT (C.T.) and AMED (M.K.) and by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (26241016, 26250024, 16K12606 to M.K, 16H06403, 16H06400 to M.M., 17H06060 to M.N., and 17H07032 to N.E.), and from MHLW (201624007 A) (M.K.). We thank Manami Kakita and Kazuki Kyoso for technical assistance with Experiment 1. We thank Dr. Sigeharu Wakana of RIKEN BioResource Center (BRC) and Dr. Kentaro Tanemura of Tohoku University for their helpful discussions. The English language review by Enago (http://www.enago.com) and Nature Research Editing Service (http://authorservices.springernature.com/) is greatly appreciated.
Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Social relationships are a key determinant of social behaviour, and disruption of social behaviour is a major symptom of several psychiatric disorders. However, few studies have analysed social relationships among multiple individuals in a group or how social relationships within a group influence the behaviour of members with impaired socialisation. Here, we developed a video-analysis-based system, the Multiple-Animal Positioning System (MAPS), to automatically and separately analyse the social behaviour of multiple individuals in group housing. Using MAPS, we show that social isolation of male mice during adolescence leads to impaired social proximity in adulthood. The phenotype of these socially isolated mice was partially rescued by cohabitation with group-housed (socially-reared) mice, indicating that both individual behavioural traits and those of cagemates influence social proximity. Furthermore, we demonstrate that low reactive behaviour of other cagemates also influence individual social proximity in male mice.
AB - Social relationships are a key determinant of social behaviour, and disruption of social behaviour is a major symptom of several psychiatric disorders. However, few studies have analysed social relationships among multiple individuals in a group or how social relationships within a group influence the behaviour of members with impaired socialisation. Here, we developed a video-analysis-based system, the Multiple-Animal Positioning System (MAPS), to automatically and separately analyse the social behaviour of multiple individuals in group housing. Using MAPS, we show that social isolation of male mice during adolescence leads to impaired social proximity in adulthood. The phenotype of these socially isolated mice was partially rescued by cohabitation with group-housed (socially-reared) mice, indicating that both individual behavioural traits and those of cagemates influence social proximity. Furthermore, we demonstrate that low reactive behaviour of other cagemates also influence individual social proximity in male mice.
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U2 - 10.1038/s42003-018-0213-5
DO - 10.1038/s42003-018-0213-5
M3 - Article
C2 - 31924861
AN - SCOPUS:85071182546
VL - 1
JO - Communications Biology
JF - Communications Biology
SN - 2399-3642
IS - 1
M1 - 225
ER -