Muscarinic receptor occupancy by biperiden in living human brain

Yasuhiko Sudo, Tetsuya Suhara, Kazutoshi Suzuki, Yoshiro Okubo, Kyosan Yoshikawa, Sunao Uchida, Takeshi Sassa, Takashi Okauchi, Yasuhito Sasaki, Masaaki Matsushita

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Anticholinergic drug is often used to treat extrapyramidal symptoms. We measured muscarinic cholinergic receptor (mAchR) occupancy by the oral administration of biperiden in eight healthy subjects using positron emission tomography (PET) and [11C]N-methyl-4-piperidylbenzilate (NMPB). After the baseline scan each subject underwent one or two post-dose PET scans, mAchR occupancy was 10-45% in the frontal cortex three hours after the oral administration of 4 mg of biperiden. The occupancy correlated with the plasma concentration of biperiden in a curvilinear manner.

本文言語English
ジャーナルLife Sciences
64
8
出版ステータスPublished - 1999 1 15
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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