TY - JOUR
T1 - Muscle metaboreflex activation by static exercise dilates pupil in humans
AU - Hayashi, Naoyuki
AU - Someya, Nami
N1 - Funding Information:
Acknowledgments This study was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sport, Culture, and Technology of Japan (no. 21370111).
PY - 2011/6
Y1 - 2011/6
N2 - We examined a hypothesis that static exercise and activation of sympathetic activation by metabolically sensitive skeletal muscle afferents (metaboreflex) influence the sympathetic nervous activity modulating pupil diameter. Nine subjects performed 2 min isometric handgrip exercise at 30% maximal voluntary contraction, which was followed by either 2 min of postexercise muscle ischemia (PEMI) in the forearm or no PEMI (control trial). The pupil diameter and mean blood pressure (MAP) increased significantly from rest during exercise in PEMI and control trials (5 ± 1 and 7 ± 1% in diameter; 13 ± 2 and 12 ± 2 mmHg in MAP, respectively). These increases in the diameter and MAP were maintained during PEMI (7 ± 2% and 9 ± 2 mmHg) but not during the recovery period in the control trial (3 ± 2% and 1 ± 2 mmHg). These results demonstrate that static handgrip exercise increases the pupil diameter, and this increase is partly due to the activation of metaboreflex in humans.
AB - We examined a hypothesis that static exercise and activation of sympathetic activation by metabolically sensitive skeletal muscle afferents (metaboreflex) influence the sympathetic nervous activity modulating pupil diameter. Nine subjects performed 2 min isometric handgrip exercise at 30% maximal voluntary contraction, which was followed by either 2 min of postexercise muscle ischemia (PEMI) in the forearm or no PEMI (control trial). The pupil diameter and mean blood pressure (MAP) increased significantly from rest during exercise in PEMI and control trials (5 ± 1 and 7 ± 1% in diameter; 13 ± 2 and 12 ± 2 mmHg in MAP, respectively). These increases in the diameter and MAP were maintained during PEMI (7 ± 2% and 9 ± 2 mmHg) but not during the recovery period in the control trial (3 ± 2% and 1 ± 2 mmHg). These results demonstrate that static handgrip exercise increases the pupil diameter, and this increase is partly due to the activation of metaboreflex in humans.
KW - Exercise pressor reflex
KW - Postexercise muscle ischemia
KW - Pupil diameter
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U2 - 10.1007/s00421-010-1716-z
DO - 10.1007/s00421-010-1716-z
M3 - Article
C2 - 21076842
AN - SCOPUS:79958111410
SN - 1439-6319
VL - 111
SP - 1217
EP - 1221
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 6
ER -
