Muscle plasticity and β 2-adrenergic receptors: Adaptive responses of β 2-adrenergic receptor expression to muscle hypertrophy and atrophy

Shogo Sato, Ken Shirato, Kaoru Tachiyashiki, Kazuhiko Imaizumi*


    研究成果: Article査読

    36 被引用数 (Scopus)


    We discuss the functional roles of β 2 -adrenergic receptors in skeletal muscle hypertrophy and atrophy as well as the adaptive responses of 2 -adrenergic receptor expression to anabolic and catabolic conditions. β 2-Adrenergic receptor stimulation using anabolic drugs increases muscle mass by promoting muscle protein synthesis and/or attenuating protein degradation. These effects are prevented by the downregulation of the receptor. Endurance training improves oxidative performance partly by increasing β 2-adrenergic receptor density in exercise-recruited slow-twitch muscles. However, excessive stimulation of β 2- adrenergic receptors negates their beneficial effects. Although the preventive effects of β 2-adrenergic receptor stimulation on atrophy induced by muscle disuse and catabolic hormones or drugs are observed, these catabolic conditions decrease β 2-adrenergic receptor expression in slow-twitch muscles. These findings present evidence against the use of β 2-adrenergic agonists in therapy for muscle wasting and weakness. Thus, β 2-adrenergic receptors in the skeletal muscles play an important physiological role in the regulation of protein and energy balance.

    ジャーナルJournal of Biomedicine and Biotechnology
    出版ステータスPublished - 2011

    ASJC Scopus subject areas

    • バイオテクノロジー
    • 分子医療
    • 遺伝学
    • 分子生物学
    • 健康、毒物学および変異誘発
    • 医学(全般)


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