Myocardial sarcomeres spontaneously oscillate with the period of heartbeat under physiological conditions

Daisuke Sasaki, Norio Fukuda, Shin'ichi Ishiwata*

*この研究の対応する著者

    研究成果: Article査読

    24 被引用数 (Scopus)

    抄録

    During heartbeat, the repeated contractions of myocardium are induced by the oscillation of intracellular Ca2+ concentration. On the other hand, when intermediately activated at a certain Ca2+ concentration, cardiac myofibrils exhibit the spontaneous sarcomeric oscillation (Ca-SPOC) under steady ionic conditions. In the present study, we found that Ca-SPOC occurred over a wide range of Ca2+ concentrations, including physiological contractile conditions, in skinned myocardium prepared from various animal species (rat, rabbit, pig, and cow). The period of sarcomeric oscillation fell within the same range as the period of heartbeat of each animal species. On the basis of these results we propose that the intrinsic auto-oscillatory property of sarcomeres (myofibrils) significantly contributes to myocardial beating in vivo.

    本文言語English
    ページ(範囲)1146-1152
    ページ数7
    ジャーナルBiochemical and Biophysical Research Communications
    343
    4
    DOI
    出版ステータスPublished - 2006 5月 19

    ASJC Scopus subject areas

    • 生化学
    • 生物理学
    • 分子生物学

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