Myosins and cell dynamics in cellular slime molds

Shigehiko Yumura, Taro Q.P. Uyeda

研究成果: Review article査読

38 被引用数 (Scopus)

抄録

Myosin is a mechanochemical transducer and serves as a motor for various motile activities such as cell migration, cytokinesis, maintenance of cell shape, phagocytosis, and morphogenesis. Nonmuscle myosin in vivo does not either stay static at specific subcellular regions or construct highly organized structures, such as sarcomere in skeletal muscle cells. The cellular slime mold Dictyostelium discoideum is an ideal "model organism" for the investigation of cell movement and cytokinesis. The advantages of this organism prompted researchers to carry out pioneering cell biological, biochemical, and molecular genetic studies on myosin II, which resulted in elucidation of many fundamental features of function and regulation of this most abundant molecular motor. Furthermore, recent molecular biological research has revealed that many unconventional myosins play various functions in vivo. In this article, how myosins are organized and regulated in a dynamic manner in Dictyostelium cells is reviewed and discussed.

本文言語English
ページ(範囲)173-225
ページ数53
ジャーナルInternational Review of Cytology
224
DOI
出版ステータスPublished - 2003
外部発表はい

ASJC Scopus subject areas

  • Histology
  • Cell Biology

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