Myotube formation on gelatin nanofibers - Multi-walled carbon nanotubes hybrid scaffolds

Serge Ostrovidov, Xuetao Shi, Ling Zhang, Xiaobin Liang, Sang Bok Kim, Toshinori Fujie, Murugan Ramalingam, Mingwei Chen, Ken Nakajima, Faten Al-Hazmi, Hojae Bae, Adnan Memic, Ali Khademhosseini*

*この研究の対応する著者

研究成果: Article査読

89 被引用数 (Scopus)

抄録

Engineering functional muscle tissue requires the formation of densely packed, aligned, and mature myotubes. To enhance the formation of aligned myotubes with improved contractibility, we fabricated aligned electrospun gelatin multi-walled carbon nanotubes (MWNTs) hybrid fibers that were used as scaffolds for the growth of myoblasts (C2C12). The MWNTs significantly enhanced myotube formation by improving the mechanical properties of the resulting fibers and upregulated the activation of mechanotransduction related genes. In addition, the fibers enhanced the maturation of the myotubes and the amplitude of the myotube contractions under electrical stimulation (ES). Such hybrid material scaffolds may be useful to direct skeletal muscle cellular organization, improve cellular functionality and tissue formation.

本文言語English
ページ(範囲)6268-6277
ページ数10
ジャーナルBiomaterials
35
24
DOI
出版ステータスPublished - 2014

ASJC Scopus subject areas

  • 生体材料
  • バイオエンジニアリング
  • セラミックおよび複合材料
  • 材料力学
  • 生物理学
  • 医学(全般)

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