N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H647

Julius Adam V. Lopez, Toshihiko Nogawa, Yushi Futamura, Harumi Aono, Daisuke Hashizume, Hiroyuki Osada*

*この研究の対応する著者

研究成果: Article査読

抄録

N-acetyl-α-hydroxy-β-oxotryptamine (1) along with N-acetyl-β-oxotryptamine (2) and pimprinine (3) were isolated from the culture broth of Streptomyces sp. 80H647. Compound 1 was found to be a racemate via X-ray diffraction analysis and the enantiomers were successfully purified by chiral-phase HPLC. The absolute configuration was assigned by comparison of the calculated and experimental ECD spectra. The α-hydroxy moiety of 1 was vital for cytotoxicity against different cancer cell lines.

本文言語English
ページ(範囲)477-479
ページ数3
ジャーナルJournal of Antibiotics
74
7
DOI
出版ステータスPublished - 2021 7月
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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