Nanaomycin K, a new epithelial–mesenchymal transition inhibitor produced by the actinomycete “Streptomyces rosa subsp. notoensis” OS-3966

Hirotaka Matsuo, Jun Nakanishi, Yoshihiko Noguchi, Koichi Kitagawa, Katsumi Shigemura, Toshiaki Sunazuka, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A new nanaomycin analog, nanaomycin K, was isolated from a cultured broth of actinomycete strain “Streptomyces rosa subsp. notoensis” OS-3966. Nuclear magnetic resonance (NMR) analyses revealed that the planar structure of nanaomycin K had an ergothioneine moiety. To determine the absolute configuration, nanaomycin K was semisynthesized using standards of nanaomycin E and L-ergothioneine. The natural and semisynthetic nanaomycin K were identified as the same compounds based on retention time, mass spectrometry, 1H NMR, and optical rotation data. Nanaomycin K showed cytotoxicity against Madin–Darby canine kidney (MDCK) cells undergoing transforming growth factor (TGF) β1-induced epithelial–mesenchymal transition.

本文言語English
ページ(範囲)291-295
ページ数5
ジャーナルJournal of Bioscience and Bioengineering
129
3
DOI
出版ステータスPublished - 2020 3
外部発表はい

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

フィンガープリント 「Nanaomycin K, a new epithelial–mesenchymal transition inhibitor produced by the actinomycete “Streptomyces rosa subsp. notoensis” OS-3966」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル