Neonatal expression of progesterone receptor isoforms in the cerebellar Purkinje cell in rats

Hirotaka Sakamoto, Hanako Shikimi, Kazuyoshi Ukena, Kazuyoshi Tsutsui*

*この研究の対応する著者

研究成果査読

34 被引用数 (Scopus)

抄録

The cerebellar Purkinje cell (PC) is a typical site for neurosteroid formation. Progesterone synthesized de novo in developing PCs participates in the promotion of dendritic growth, spinogenesis and synaptogenesis in this neuron and such organizing actions may contribute to the formation of the cerebellar neuronal circuit during rat neonatal life. Progesterone receptors (PR) occur as two isoforms (PR-A and PR-B) derived from a single gene. To clarify the mode of organizing actions of progesterone, therefore, we examined the expression of these PR isoforms in the rat cerebellum during development. Western immunoblot analysis revealed that both PR isoforms were expressed highly in the cerebellum during neonatal life and the expression decreased thereafter. PR-like immunoreactivity was localized primarily in PCs in the neonatal cerebellum. Thus, progesterone may act directly on PCs via PR isoforms to promote its dendritic growth, spinogenesis and synaptogenesis.

本文言語English
ページ(範囲)163-166
ページ数4
ジャーナルNeuroscience Letters
343
3
DOI
出版ステータスPublished - 2003 6 12
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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