抄録
We report on the results of culturing SH-SY5Y neuron-like cells on PEDOT:PSS wrinkled surfaces fabricated by thermally-induced shrinking of commercial polystyrene sheets. Such smart biointerfaces combine the functional properties of conducting polymers with the topographic patterning at the micro-and sub-microscale, as a result of surface wrinkling. By imposing mechanical constraints during shrinking, anisotropic topographic features are formed, with a spatial periodicity in the range 0.7-1.2 um, tunable by varying the thickness of the PEDOT:PSS thin film. The effectiveness of wrinkled surfaces in enhancing and orientating the outgrowth of neurites is demonstrated by a 42% increase in length and by the 85% of neuntes aligned along wrinkles direction (angle 0 < 9< 15°), after 5 days of differentiation. Furthermore, the conductive properties of the PEDOT:PSS film are retained after the surface wrinkling, opening the way for the exploitation of these smart biointerfaces for the electrical stimulation of cells.
| 元の言語 | English |
|---|---|
| ホスト出版物のタイトル | Organic Bioelectronics - Materials, Processes and Applications |
| 出版者 | Materials Research Society |
| ページ | 13-18 |
| ページ数 | 6 |
| 巻 | 1795 |
| ISBN（電子版） | 9781510826489 |
| DOI | |
| 出版物ステータス | Published - 2015 |
| 外部発表 | Yes |
| イベント | 2015 MRS Spring Meeting - San Francisco, United States 継続期間: 2015 4 6 → 2015 4 10 |
Other
| Other | 2015 MRS Spring Meeting |
|---|---|
| 国 | United States |
| 市 | San Francisco |
| 期間 | 15/4/6 → 15/4/10 |
Fingerprint
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering
これを引用
Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates. / Bonisoli, Alberto; Marino, Attilio; Ciofani, Gianni; Greco, Francesco.
Organic Bioelectronics - Materials, Processes and Applications. 巻 1795 Materials Research Society, 2015. p. 13-18.研究成果: Conference contribution
}
TY - GEN
T1 - Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates
AU - Bonisoli, Alberto
AU - Marino, Attilio
AU - Ciofani, Gianni
AU - Greco, Francesco
PY - 2015
Y1 - 2015
N2 - We report on the results of culturing SH-SY5Y neuron-like cells on PEDOT:PSS wrinkled surfaces fabricated by thermally-induced shrinking of commercial polystyrene sheets. Such smart biointerfaces combine the functional properties of conducting polymers with the topographic patterning at the micro-and sub-microscale, as a result of surface wrinkling. By imposing mechanical constraints during shrinking, anisotropic topographic features are formed, with a spatial periodicity in the range 0.7-1.2 um, tunable by varying the thickness of the PEDOT:PSS thin film. The effectiveness of wrinkled surfaces in enhancing and orientating the outgrowth of neurites is demonstrated by a 42% increase in length and by the 85% of neuntes aligned along wrinkles direction (angle 0 < 9< 15°), after 5 days of differentiation. Furthermore, the conductive properties of the PEDOT:PSS film are retained after the surface wrinkling, opening the way for the exploitation of these smart biointerfaces for the electrical stimulation of cells.
AB - We report on the results of culturing SH-SY5Y neuron-like cells on PEDOT:PSS wrinkled surfaces fabricated by thermally-induced shrinking of commercial polystyrene sheets. Such smart biointerfaces combine the functional properties of conducting polymers with the topographic patterning at the micro-and sub-microscale, as a result of surface wrinkling. By imposing mechanical constraints during shrinking, anisotropic topographic features are formed, with a spatial periodicity in the range 0.7-1.2 um, tunable by varying the thickness of the PEDOT:PSS thin film. The effectiveness of wrinkled surfaces in enhancing and orientating the outgrowth of neurites is demonstrated by a 42% increase in length and by the 85% of neuntes aligned along wrinkles direction (angle 0 < 9< 15°), after 5 days of differentiation. Furthermore, the conductive properties of the PEDOT:PSS film are retained after the surface wrinkling, opening the way for the exploitation of these smart biointerfaces for the electrical stimulation of cells.
UR - http://www.scopus.com/inward/record.url?scp=84985917029&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84985917029&partnerID=8YFLogxK
U2 - 10.1557/opl.2015.558
DO - 10.1557/opl.2015.558
M3 - Conference contribution
AN - SCOPUS:84985917029
VL - 1795
SP - 13
EP - 18
BT - Organic Bioelectronics - Materials, Processes and Applications
PB - Materials Research Society
ER -