Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates

Alberto Bonisoli, Attilio Marino, Gianni Ciofani, Francesco Greco

研究成果: Conference contribution

抄録

We report on the results of culturing SH-SY5Y neuron-like cells on PEDOT:PSS wrinkled surfaces fabricated by thermally-induced shrinking of commercial polystyrene sheets. Such smart biointerfaces combine the functional properties of conducting polymers with the topographic patterning at the micro-and sub-microscale, as a result of surface wrinkling. By imposing mechanical constraints during shrinking, anisotropic topographic features are formed, with a spatial periodicity in the range 0.7-1.2 um, tunable by varying the thickness of the PEDOT:PSS thin film. The effectiveness of wrinkled surfaces in enhancing and orientating the outgrowth of neurites is demonstrated by a 42% increase in length and by the 85% of neuntes aligned along wrinkles direction (angle 0 < 9< 15°), after 5 days of differentiation. Furthermore, the conductive properties of the PEDOT:PSS film are retained after the surface wrinkling, opening the way for the exploitation of these smart biointerfaces for the electrical stimulation of cells.

元の言語English
ホスト出版物のタイトルOrganic Bioelectronics - Materials, Processes and Applications
出版者Materials Research Society
ページ13-18
ページ数6
1795
ISBN(電子版)9781510826489
DOI
出版物ステータスPublished - 2015
外部発表Yes
イベント2015 MRS Spring Meeting - San Francisco, United States
継続期間: 2015 4 62015 4 10

Other

Other2015 MRS Spring Meeting
United States
San Francisco
期間15/4/615/4/10

Fingerprint

Conducting polymers
conducting polymers
alignment
wrinkling
Substrates
Polystyrenes
exploitation
cells
neurons
stimulation
microbalances
Neurons
periodic variations
polystyrene
Thin films
thin films
poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

これを引用

Bonisoli, A., Marino, A., Ciofani, G., & Greco, F. (2015). Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates. : Organic Bioelectronics - Materials, Processes and Applications (巻 1795, pp. 13-18). Materials Research Society. https://doi.org/10.1557/opl.2015.558

Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates. / Bonisoli, Alberto; Marino, Attilio; Ciofani, Gianni; Greco, Francesco.

Organic Bioelectronics - Materials, Processes and Applications. 巻 1795 Materials Research Society, 2015. p. 13-18.

研究成果: Conference contribution

Bonisoli, A, Marino, A, Ciofani, G & Greco, F 2015, Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates. : Organic Bioelectronics - Materials, Processes and Applications. 巻. 1795, Materials Research Society, pp. 13-18, 2015 MRS Spring Meeting, San Francisco, United States, 15/4/6. https://doi.org/10.1557/opl.2015.558
Bonisoli A, Marino A, Ciofani G, Greco F. Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates. : Organic Bioelectronics - Materials, Processes and Applications. 巻 1795. Materials Research Society. 2015. p. 13-18 https://doi.org/10.1557/opl.2015.558
Bonisoli, Alberto ; Marino, Attilio ; Ciofani, Gianni ; Greco, Francesco. / Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates. Organic Bioelectronics - Materials, Processes and Applications. 巻 1795 Materials Research Society, 2015. pp. 13-18
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