Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates

Alberto Bonisoli, Attilio Marino, Gianni Ciofani, Francesco Greco

研究成果: Conference contribution

抄録

We report on the results of culturing SH-SY5Y neuron-like cells on PEDOT:PSS wrinkled surfaces fabricated by thermally-induced shrinking of commercial polystyrene sheets. Such smart biointerfaces combine the functional properties of conducting polymers with the topographic patterning at the micro-and sub-microscale, as a result of surface wrinkling. By imposing mechanical constraints during shrinking, anisotropic topographic features are formed, with a spatial periodicity in the range 0.7-1.2 um, tunable by varying the thickness of the PEDOT:PSS thin film. The effectiveness of wrinkled surfaces in enhancing and orientating the outgrowth of neurites is demonstrated by a 42% increase in length and by the 85% of neuntes aligned along wrinkles direction (angle 0 < 9< 15°), after 5 days of differentiation. Furthermore, the conductive properties of the PEDOT:PSS film are retained after the surface wrinkling, opening the way for the exploitation of these smart biointerfaces for the electrical stimulation of cells.

本文言語English
ホスト出版物のタイトルOrganic Bioelectronics - Materials, Processes and Applications
出版社Materials Research Society
ページ13-18
ページ数6
1795
ISBN(電子版)9781510826489
DOI
出版ステータスPublished - 2015
外部発表はい
イベント2015 MRS Spring Meeting - San Francisco, United States
継続期間: 2015 4月 62015 4月 10

Other

Other2015 MRS Spring Meeting
国/地域United States
CitySan Francisco
Period15/4/615/4/10

ASJC Scopus subject areas

  • 材料科学(全般)
  • 凝縮系物理学
  • 材料力学
  • 機械工学

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