抄録
We report on the results of culturing SH-SY5Y neuron-like cells on PEDOT:PSS wrinkled surfaces fabricated by thermally-induced shrinking of commercial polystyrene sheets. Such smart biointerfaces combine the functional properties of conducting polymers with the topographic patterning at the micro-and sub-microscale, as a result of surface wrinkling. By imposing mechanical constraints during shrinking, anisotropic topographic features are formed, with a spatial periodicity in the range 0.7-1.2 um, tunable by varying the thickness of the PEDOT:PSS thin film. The effectiveness of wrinkled surfaces in enhancing and orientating the outgrowth of neurites is demonstrated by a 42% increase in length and by the 85% of neuntes aligned along wrinkles direction (angle 0 < 9< 15°), after 5 days of differentiation. Furthermore, the conductive properties of the PEDOT:PSS film are retained after the surface wrinkling, opening the way for the exploitation of these smart biointerfaces for the electrical stimulation of cells.
本文言語 | English |
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ホスト出版物のタイトル | Organic Bioelectronics - Materials, Processes and Applications |
出版社 | Materials Research Society |
ページ | 13-18 |
ページ数 | 6 |
巻 | 1795 |
ISBN(電子版) | 9781510826489 |
DOI | |
出版ステータス | Published - 2015 |
外部発表 | はい |
イベント | 2015 MRS Spring Meeting - San Francisco, United States 継続期間: 2015 4月 6 → 2015 4月 10 |
Other
Other | 2015 MRS Spring Meeting |
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国/地域 | United States |
City | San Francisco |
Period | 15/4/6 → 15/4/10 |
ASJC Scopus subject areas
- 材料科学(全般)
- 凝縮系物理学
- 材料力学
- 機械工学