Neurosteroid biosynthesis and function in the brain of domestic birds

Kazuyoshi Tsutsui*

*この研究の対応する著者

    研究成果: Article査読

    21 被引用数 (Scopus)

    抄録

    It is now established that the brain and other nervous systems have the capability of form-ing steroids de novo, the so-called "neurosteroids." The pioneering discovery of Baulieu and his colleagues, using rodents, has opened the door to a new research field of "neuros-teroids." In contrast to mammalian vertebrates, little has been known regarding de novo neurosteroidogenesis in the brain of birds. We therefore investigated neurosteroid forma-tion and metabolism in the brain of quail, a domestic bird. Our studies over the past two decades demonstrated that the quail brain possesses cytochrome P450 side-chain cleav-age enzyme (P450scc), 3β-hydroxysteroid dehydrogenase/Δ54-isomerase (3β-HSD), 5β-reductase, cytochrome P45017α-hydroxylase/c17,20-lyase (P45017α,lyase), 17β-HSD, etc., and produces pregnenolone, progesterone, 5β-dihydroprogesterone (5β-DHP), 3β, 5β-tetrahydroprogesterone (3β,5β-THP), androstenedione, testosterone, and estradiol from cholesterol. Independently, Schlinger's laboratory demonstrated that the brain of zebra finch, a songbird, also produces various neurosteroids.Thus, the formation and metabolism of neurosteroids from cholesterol is now known to occur in the brain of birds. In addition, we recently found that the quail brain expresses cytochrome P450 and produces 7α-and 7β-hydroxypregnenolone, previously undescribed avian neurosteroids, from pregnenolone. This paper summarizes the advances made in our understanding of neurosteroid formation and metabolism in the brain of domestic birds.This paper also describes what are currently known about physiological changes in neurosteroid formation and biological functions of neurosteroids in the brain of domestic and other birds.

    本文言語English
    論文番号Article 37
    ジャーナルFrontiers in Endocrinology
    2
    SEP
    DOI
    出版ステータスPublished - 2011

    ASJC Scopus subject areas

    • 内分泌学、糖尿病および代謝内科学

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