Neurosteroid biosynthesis in the brain of amphibians

Hubert Vaudry, Jean Luc Do Rego, Delphine Burel, Van Luu-The, Georges Pelletier, David Vaudry, Kazuyoshi Tsutsui

    研究成果: Article

    9 引用 (Scopus)

    抄録

    Amphibians have been widely used to investigate the synthesis of biologically active steroids in the brain and the regulation of neurosteroid production by neurotransmitters and neuropeptides. The aim of the present review is to summarize the current knowl- edge regarding the neuroanatomical distribution and biochemical activity of steroidogenic enzymes in the brain of anurans and urodeles. The data accumulated over the past two decades demonstrate that discrete populations of neurons and/or glial cells in the frog and newt brains express the major steroidogenic enzymes and are able to synthesize de novo a number of neurosteroids from cholesterol/pregnenolone. Since neurosteroidogen- esis has been conserved during evolution from amphibians to mammals, it appears that neurosteroids must play important physiological functions in the central nervous system of vertebrates.

    元の言語English
    記事番号Article 79
    ジャーナルFrontiers in Endocrinology
    2
    発行部数NOV
    DOI
    出版物ステータスPublished - 2011

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    Amphibians
    Neurotransmitter Agents
    Brain
    Salamandridae
    Pregnenolone
    Enzymes
    Neuropeptides
    Neuroglia
    Anura
    Vertebrates
    Mammals
    Central Nervous System
    Steroids
    Cholesterol
    Neurons
    Population

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism

    これを引用

    Vaudry, H., Rego, J. L. D., Burel, D., Luu-The, V., Pelletier, G., Vaudry, D., & Tsutsui, K. (2011). Neurosteroid biosynthesis in the brain of amphibians. Frontiers in Endocrinology, 2(NOV), [Article 79]. https://doi.org/10.3389/fendo.2011.00079

    Neurosteroid biosynthesis in the brain of amphibians. / Vaudry, Hubert; Rego, Jean Luc Do; Burel, Delphine; Luu-The, Van; Pelletier, Georges; Vaudry, David; Tsutsui, Kazuyoshi.

    :: Frontiers in Endocrinology, 巻 2, 番号 NOV, Article 79, 2011.

    研究成果: Article

    Vaudry, H, Rego, JLD, Burel, D, Luu-The, V, Pelletier, G, Vaudry, D & Tsutsui, K 2011, 'Neurosteroid biosynthesis in the brain of amphibians', Frontiers in Endocrinology, 巻. 2, 番号 NOV, Article 79. https://doi.org/10.3389/fendo.2011.00079
    Vaudry H, Rego JLD, Burel D, Luu-The V, Pelletier G, Vaudry D その他. Neurosteroid biosynthesis in the brain of amphibians. Frontiers in Endocrinology. 2011;2(NOV). Article 79. https://doi.org/10.3389/fendo.2011.00079
    Vaudry, Hubert ; Rego, Jean Luc Do ; Burel, Delphine ; Luu-The, Van ; Pelletier, Georges ; Vaudry, David ; Tsutsui, Kazuyoshi. / Neurosteroid biosynthesis in the brain of amphibians. :: Frontiers in Endocrinology. 2011 ; 巻 2, 番号 NOV.
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