Neurosteroids and synaptic formation in the cerebellum

    研究成果: Chapter

    抄録

    The cerebellar cortex has been used as an excellent model to study synaptic formation and transmission of neural networks because it forms relatively simple neuronal networks compared to those of other brain regions. The formation of the mammalian cerebellar cortex becomes complete in the neonate through the processes of migration of external granule cells, neuronal and glial growth, and synaptogenesis. It is important to clarify the mechanism underlying synaptic formation of cerebellar neuronal networks during development. The brain has traditionally been considered to be a target site of peripheral steroid hormones. In contrast to this classical concept, new findings have shown that the brain has the capacity to synthesize steroids de novo from cholesterol, the so-called neurosteroids. In the middle 1990s, the Purkinje cell, a principal cerebellar neuron, was identified as a major site for neurosteroid formation in mammals as well as other vertebrates. This discovery has provided the opportunity to understand neuronal neurosteroidogenesis in the brain. In addition, biological actions of neurosteroids have become clear by the studies using the Purkinje cell as an excellent cellular model, which is known to play an important role in memory and learning processes. Based on extensive studies on mammals over the past decade, it is considered that the Purkinje cell actively synthesizes progesterone and estradiol de novo from cholesterol during neonatal life, when cerebellar neuronal circuit formation occurs. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such neurosteroid actions that may be mediated by neurotrophic factors contribute to the formation of cerebellar neuronal circuit during neonatal life. Allopregnanolone (3,5-tetrahydroprogesterone), a progesterone metabolite, is also synthesized in the cerebellum and acts on Purkinje cell survival in the neonate. This chapter summarizes the current knowledge regarding the biosynthesis and biological actions of neurosteroids in the cerebellum during development in terms of synaptic formation of cerebellar neuronal networks.

    元の言語English
    ホスト出版物のタイトルHandbook of the Cerebellum and Cerebellar Disorders
    出版者Springer Netherlands
    ページ993-1012
    ページ数20
    ISBN(電子版)9789400713338
    ISBN(印刷物)9789400713321
    DOI
    出版物ステータスPublished - 2013 1 1

    Fingerprint

    Purkinje Cells
    Cerebellum
    Neurotransmitter Agents
    Progesterone
    Cerebellar Cortex
    Brain
    Mammals
    Estradiol
    Steroids
    Cholesterol
    Pregnanolone
    Nerve Growth Factors
    Cytoplasmic and Nuclear Receptors
    Growth
    Synaptic Transmission
    Neuroglia
    Vertebrates
    Cell Survival
    Learning
    Hormones

    ASJC Scopus subject areas

    • Medicine(all)
    • Neuroscience(all)

    これを引用

    Tsutsui, K. (2013). Neurosteroids and synaptic formation in the cerebellum. : Handbook of the Cerebellum and Cerebellar Disorders (pp. 993-1012). Springer Netherlands. https://doi.org/10.1007/978-94-007-1333-8_42

    Neurosteroids and synaptic formation in the cerebellum. / Tsutsui, Kazuyoshi.

    Handbook of the Cerebellum and Cerebellar Disorders. Springer Netherlands, 2013. p. 993-1012.

    研究成果: Chapter

    Tsutsui, K 2013, Neurosteroids and synaptic formation in the cerebellum. : Handbook of the Cerebellum and Cerebellar Disorders. Springer Netherlands, pp. 993-1012. https://doi.org/10.1007/978-94-007-1333-8_42
    Tsutsui K. Neurosteroids and synaptic formation in the cerebellum. : Handbook of the Cerebellum and Cerebellar Disorders. Springer Netherlands. 2013. p. 993-1012 https://doi.org/10.1007/978-94-007-1333-8_42
    Tsutsui, Kazuyoshi. / Neurosteroids and synaptic formation in the cerebellum. Handbook of the Cerebellum and Cerebellar Disorders. Springer Netherlands, 2013. pp. 993-1012
    @inbook{c72d85b21fe24e2bbbd9f4f8f2a197fa,
    title = "Neurosteroids and synaptic formation in the cerebellum",
    abstract = "The cerebellar cortex has been used as an excellent model to study synaptic formation and transmission of neural networks because it forms relatively simple neuronal networks compared to those of other brain regions. The formation of the mammalian cerebellar cortex becomes complete in the neonate through the processes of migration of external granule cells, neuronal and glial growth, and synaptogenesis. It is important to clarify the mechanism underlying synaptic formation of cerebellar neuronal networks during development. The brain has traditionally been considered to be a target site of peripheral steroid hormones. In contrast to this classical concept, new findings have shown that the brain has the capacity to synthesize steroids de novo from cholesterol, the so-called neurosteroids. In the middle 1990s, the Purkinje cell, a principal cerebellar neuron, was identified as a major site for neurosteroid formation in mammals as well as other vertebrates. This discovery has provided the opportunity to understand neuronal neurosteroidogenesis in the brain. In addition, biological actions of neurosteroids have become clear by the studies using the Purkinje cell as an excellent cellular model, which is known to play an important role in memory and learning processes. Based on extensive studies on mammals over the past decade, it is considered that the Purkinje cell actively synthesizes progesterone and estradiol de novo from cholesterol during neonatal life, when cerebellar neuronal circuit formation occurs. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such neurosteroid actions that may be mediated by neurotrophic factors contribute to the formation of cerebellar neuronal circuit during neonatal life. Allopregnanolone (3,5-tetrahydroprogesterone), a progesterone metabolite, is also synthesized in the cerebellum and acts on Purkinje cell survival in the neonate. This chapter summarizes the current knowledge regarding the biosynthesis and biological actions of neurosteroids in the cerebellum during development in terms of synaptic formation of cerebellar neuronal networks.",
    author = "Kazuyoshi Tsutsui",
    year = "2013",
    month = "1",
    day = "1",
    doi = "10.1007/978-94-007-1333-8_42",
    language = "English",
    isbn = "9789400713321",
    pages = "993--1012",
    booktitle = "Handbook of the Cerebellum and Cerebellar Disorders",
    publisher = "Springer Netherlands",

    }

    TY - CHAP

    T1 - Neurosteroids and synaptic formation in the cerebellum

    AU - Tsutsui, Kazuyoshi

    PY - 2013/1/1

    Y1 - 2013/1/1

    N2 - The cerebellar cortex has been used as an excellent model to study synaptic formation and transmission of neural networks because it forms relatively simple neuronal networks compared to those of other brain regions. The formation of the mammalian cerebellar cortex becomes complete in the neonate through the processes of migration of external granule cells, neuronal and glial growth, and synaptogenesis. It is important to clarify the mechanism underlying synaptic formation of cerebellar neuronal networks during development. The brain has traditionally been considered to be a target site of peripheral steroid hormones. In contrast to this classical concept, new findings have shown that the brain has the capacity to synthesize steroids de novo from cholesterol, the so-called neurosteroids. In the middle 1990s, the Purkinje cell, a principal cerebellar neuron, was identified as a major site for neurosteroid formation in mammals as well as other vertebrates. This discovery has provided the opportunity to understand neuronal neurosteroidogenesis in the brain. In addition, biological actions of neurosteroids have become clear by the studies using the Purkinje cell as an excellent cellular model, which is known to play an important role in memory and learning processes. Based on extensive studies on mammals over the past decade, it is considered that the Purkinje cell actively synthesizes progesterone and estradiol de novo from cholesterol during neonatal life, when cerebellar neuronal circuit formation occurs. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such neurosteroid actions that may be mediated by neurotrophic factors contribute to the formation of cerebellar neuronal circuit during neonatal life. Allopregnanolone (3,5-tetrahydroprogesterone), a progesterone metabolite, is also synthesized in the cerebellum and acts on Purkinje cell survival in the neonate. This chapter summarizes the current knowledge regarding the biosynthesis and biological actions of neurosteroids in the cerebellum during development in terms of synaptic formation of cerebellar neuronal networks.

    AB - The cerebellar cortex has been used as an excellent model to study synaptic formation and transmission of neural networks because it forms relatively simple neuronal networks compared to those of other brain regions. The formation of the mammalian cerebellar cortex becomes complete in the neonate through the processes of migration of external granule cells, neuronal and glial growth, and synaptogenesis. It is important to clarify the mechanism underlying synaptic formation of cerebellar neuronal networks during development. The brain has traditionally been considered to be a target site of peripheral steroid hormones. In contrast to this classical concept, new findings have shown that the brain has the capacity to synthesize steroids de novo from cholesterol, the so-called neurosteroids. In the middle 1990s, the Purkinje cell, a principal cerebellar neuron, was identified as a major site for neurosteroid formation in mammals as well as other vertebrates. This discovery has provided the opportunity to understand neuronal neurosteroidogenesis in the brain. In addition, biological actions of neurosteroids have become clear by the studies using the Purkinje cell as an excellent cellular model, which is known to play an important role in memory and learning processes. Based on extensive studies on mammals over the past decade, it is considered that the Purkinje cell actively synthesizes progesterone and estradiol de novo from cholesterol during neonatal life, when cerebellar neuronal circuit formation occurs. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such neurosteroid actions that may be mediated by neurotrophic factors contribute to the formation of cerebellar neuronal circuit during neonatal life. Allopregnanolone (3,5-tetrahydroprogesterone), a progesterone metabolite, is also synthesized in the cerebellum and acts on Purkinje cell survival in the neonate. This chapter summarizes the current knowledge regarding the biosynthesis and biological actions of neurosteroids in the cerebellum during development in terms of synaptic formation of cerebellar neuronal networks.

    UR - http://www.scopus.com/inward/record.url?scp=85039063062&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85039063062&partnerID=8YFLogxK

    U2 - 10.1007/978-94-007-1333-8_42

    DO - 10.1007/978-94-007-1333-8_42

    M3 - Chapter

    AN - SCOPUS:85039063062

    SN - 9789400713321

    SP - 993

    EP - 1012

    BT - Handbook of the Cerebellum and Cerebellar Disorders

    PB - Springer Netherlands

    ER -