New challenge for studying flow-induced blood damage: Macroscale modeling and microscale verification

T. Yagi, S. Wakasa, N. Tokunaga, Y. Akimoto, T. Akutsu, K. Iwasaki, M. Umezu

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

Prosthetic heart valves often induce blood cell trauma, but its mechanism is not clearly understood due to the complexity of dynamical flows. We herein propose a new challenge, termed macroscale modeling and microscale verification. This report is the former, and here we aim to clarify the physical interpretation of Reynolds stress for flowing cells. One polymer and two mechanical valves are compared, and the Reynolds stress is visualized using a novel analytical technique including time-resolved particle image velocimetry and continuous wavelet transform. The method enables to analyze the dynamics of Reynolds stress in a spatial and temporal domain. As a result, it is found that the Reynolds stress should be considered as an indicator of impinging flows for circulating cells. Such flows may impulsively apply a colliding force on a membrane of flowing cells. As microscale verification based on this new hypothesis, we are currently investigating such collision phenomena of flowing cells using high-speed microfluidic techniques.

本文言語English
ホスト出版物のタイトル13th International Conference on Biomedical Engineering - ICBME 2008
ページ1430-1433
ページ数4
DOI
出版ステータスPublished - 2009 12 1
イベント13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
継続期間: 2008 12 32008 12 6

出版物シリーズ

名前IFMBE Proceedings
23
ISSN(印刷版)1680-0737

Conference

Conference13th International Conference on Biomedical Engineering, ICBME 2008
CountrySingapore
Period08/12/308/12/6

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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