New compounds, nanaomycin F and G, discovered by physicochemical screening from a culture broth of Streptomyces rosa subsp. notoensis OS-3966

Takuji Nakashima, Panitch Boonsnongcheep, Toru Kimura, Masato Iwatsuki, Noriko Sato, Kenichi Nonaka, Sompop Prathanturarug, Yoko Takahashi, Satoshi Omura

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Two new compounds, nanaomycin F and G, were isolated by physicochemical screening method from cultured broth of Streptomyces rosa subsp. notoensis OS-3966, which is known to produce nanaomycin A, B, C, D, and E. Nanaomycin F is a new nanaomycin analog, a 4a-hydroxyl analog of nanaomycin B. Nanaomycin G has a unique skeleton with 1-indanone infused with a tetrahydropyran ring. Nanaomycin A possesses broad antimicrobial activity but nanaomycin F and G demonstrated no bioactivity against all bacteria and fungi tested in this study. In addition, in both nanaomycin F and G, the production of superoxide radicals was majorly decreased in comparison to nanaomycin A. It was considered that the antimicrobial properties were lost as a result of the decrease in production of the superoxide radicals.

本文言語English
ページ(範囲)596-600
ページ数5
ジャーナルJournal of Bioscience and Bioengineering
120
5
DOI
出版ステータスPublished - 2015 11
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • バイオエンジニアリング
  • 応用微生物学とバイオテクノロジー

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