New implications of memory mechanisms for Alzheimer's disease.

R. Etcheberrigaray, E. Ito, K. Oka, B. Tofel-Grehl, G. E. Gibson, D. L. Alkon

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Previous studies of molluscan and mammalian neural networks have implicated potassium channels, calcium-dependent kinases and a small G-protein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activation, we studied potassium channel function in AD. Patch-clamp experiments revealed the absence of a 113 pS TEA-sensitive K+ channel in fibroblasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.

本文言語English
ページ(範囲)S7-S10
ジャーナルNeuroscience Research Communications
12
SUPPL. 1
出版ステータスPublished - 1993 8 27
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

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