New nonlinear inversion technique for depth distribution of absorption using spatially resolved backscattering measurement

Kazuhiro Nishida, Takeshi Namita, Yuji Kato, Koichi Shimizu

研究成果: Conference contribution

3 被引用数 (Scopus)

抄録

To estimate the depth distribution of the absorption coefficient in a turbid medium, a new nonlinear inversion technique was developed. It can resolve important shortcomings of the nonlinear error of conventional linear inversion techniques. First, a turbid medium is divided into imaginary layers with arbitrary thickness. The spatial pathlength distribution (SPD) is obtained for each layer in the Monte Carlo simulation as a function of source-detector distance. In the integral operation using SPDs, we can obtain the absorption coefficient of each layer, or the depth distribution of absorption. This inversion process is based on the assumption that the light attenuation is linear with respect to the small pathlength of a photon. However, if we consider the variance of pathlength of many photons in each layer, then this assumption produces nonlinear error. We developed a technique to solve this problem in the following three steps. First, the initial values of absorption coefficient of each layer are obtained using a conventional linear inverse matrix assuming that variance of pathlength of many photons does not exist. Then, improved absorption coefficients are obtained with these initial values and the pathlength variance of many photons using the same matrix. In this way, the nonlinear error is corrected. Repeating this process, the improved absorption coefficient approaches a true value. The effectiveness of the proposed technique was confirmed in the Monte Carlo simulation. The effect of measurement noise was analyzed in the simulation.

本文言語English
ホスト出版物のタイトルOptical Tomography and Spectroscopy of Tissue X
DOI
出版ステータスPublished - 2013 5月 27
外部発表はい
イベントOptical Tomography and Spectroscopy of Tissue X - San Francisco, CA, United States
継続期間: 2013 2月 32013 2月 6

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
8578
ISSN(印刷版)1605-7422

Other

OtherOptical Tomography and Spectroscopy of Tissue X
国/地域United States
CitySan Francisco, CA
Period13/2/313/2/6

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング

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