Newt prolactin and its involvement in reproduction

S. Kikuyama*, T. Yazawa, S. Abe, K. Yamamoto, T. Iwata, K. Hoshi, I. Hasunuma, G. Mosconi, A. M. Polzonetti-Magni

*この研究の対応する著者

    研究成果査読

    23 被引用数 (Scopus)

    抄録

    The amino acid sequence of newt (Cynops pyrrhogaster) prolactin deduced from the nucleotide sequence of its cDNA showed a relatively high homology with sequences of chicken and sea turtle prolactins as well as with those of anuran prolactins. Cynops prolactin receptor transcripts were detected in various tissues and organs, suggesting that prolactin plays multiple roles in urodeles. Urodele prolactin was purified from the pituitaries of C. pyrrhogaster. Antiserum against this prolactin was used for radioimmunoassay of plasma prolactin and immunoneutralization experiments. Endogenous prolactin was shown to induce migration to water, courtship behavior, and cessation of spermatocytogenesis in the Cynops newt. The hormone was found to be involved in the development of cloacal glands such as the lateral and abdominal glands, growth of the tail and Mauthner neurons, secretion of oviducal jelly, and enhanced synthesis of a female attracting pheromone (sodefrin), and responsiveness of the olfactory epithelium to sodefrin. In most of these cases, prolactin was found to act synergistically or antagonistically with sex steroids. We also discovered that hypersecretion of prolactin in the newts subjected to cold temperature was induced by hypothalamic stimulation rather than release from hypothalamic inhibition.

    本文言語English
    ページ(範囲)984-993
    ページ数10
    ジャーナルCanadian Journal of Physiology and Pharmacology
    78
    12
    DOI
    出版ステータスPublished - 2000

    ASJC Scopus subject areas

    • 生理学
    • 薬理学

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