Night eating model shows time-specific depression-like behavior in the forced swimming test

Atsushi Haraguchi, Miyabi Fukuzawa, Shiho Iwami, Yutaro Nishimura, Hiroaki Motohashi, Yu Tahara, Shigenobu Shibata

研究成果: Article

1 引用 (Scopus)

抄録

The circadian clock system is associated with feeding and mood. Patients with night eating syndrome (NES) delay their eating rhythm and their mood declines during the evening and night, manifesting as time-specific depression. Therefore, we hypothesized that the NES feeding pattern might cause time-specific depression. We established new NES model by restricted feeding with high-fat diet during the inactive period under normal-fat diet ad libitum. The FST (forced swimming test) immobility time in the NES model group was prolonged only after lights-on, corresponding to evening and early night for humans. We examined the effect of the NES feeding pattern on peripheral clocks using PER2::LUCIFERASE knock-in mice and an in vivo monitoring system. Caloric intake during the inactive period would shift the peripheral clock, and might be an important factor in causing the time-specific depression-like behavior. In the NES model group, synthesis of serotonin and norepinephrine were increased, but utilization and metabolism of these monoamines were decreased under stress. Desipramine shortened some mice's FST immobility time in the NES model group. The present study suggests that the NES feeding pattern causes phase shift of peripheral clocks and malfunction of the monoamine system, which may contribute to the development of time-specific depression.

元の言語English
記事番号1081
ジャーナルScientific Reports
8
発行部数1
DOI
出版物ステータスPublished - 2018 12 1

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Eating
Depression
Feeding Behavior
Circadian Clocks
Desipramine
High Fat Diet
Energy Intake
Serotonin
Norepinephrine
Fats
Diet
Light

ASJC Scopus subject areas

  • General

これを引用

Night eating model shows time-specific depression-like behavior in the forced swimming test. / Haraguchi, Atsushi; Fukuzawa, Miyabi; Iwami, Shiho; Nishimura, Yutaro; Motohashi, Hiroaki; Tahara, Yu; Shibata, Shigenobu.

:: Scientific Reports, 巻 8, 番号 1, 1081, 01.12.2018.

研究成果: Article

Haraguchi, Atsushi ; Fukuzawa, Miyabi ; Iwami, Shiho ; Nishimura, Yutaro ; Motohashi, Hiroaki ; Tahara, Yu ; Shibata, Shigenobu. / Night eating model shows time-specific depression-like behavior in the forced swimming test. :: Scientific Reports. 2018 ; 巻 8, 番号 1.
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