NIK is involved in constitutive activation of the alternative NF-κB pathway and proliferation of pancreatic cancer cells

Takashi Nishina, Noritaka Yamaguchi, Jin Gohda, Kentaro Semba, Jun ichiro Inoue

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Pancreatic cancer has one of the poorest prognoses among human neoplasms. Constitutive activation of NF-κB is frequently observed in pancreatic cancer cells and is involved in their malignancy. However, little is known about the molecular mechanism of this constitutive NF-κB activation. Here, we show that the alternative pathway is constitutively activated and NF-κB-inducing kinase (NIK), a mediator of the alternative pathway, is significantly expressed in pancreatic cancer cells. siRNA-mediated silencing of NIK expression followed by subcellular fractionation revealed that NIK is constitutively involved in the processing of p100 and nuclear transport of p52 and RelB in pancreatic cancer cells. In addition, NIK silencing significantly suppressed proliferation of pancreatic cancer cells. These results clearly indicate that NIK is involved in the constitutive activation of the alternative pathway and controls cell proliferation in pancreatic cancer cells. Therefore, NIK might be a novel target for the treatment of pancreatic cancer.

本文言語English
ページ(範囲)96-101
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
388
1
DOI
出版ステータスPublished - 2009 10 9

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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