TY - JOUR
T1 - Nitric oxide suppresses fictive feeding response in Lymnaea stagnalis
AU - Kobayashi, Suguru
AU - Ogawa, Hiroto
AU - Fujito, Yutaka
AU - Ito, Etsuro
N1 - Funding Information:
This work was partly supported by a Grant-in-Aid (No. 10102001) from the Ministry of Education, Science, Sports and Culture of Japan and a grant from Narishige Zoological Science Award to E.I.
PY - 2000/5/19
Y1 - 2000/5/19
N2 - Fictive feeding activity was monitored in the buccal ganglia of semi-intact preparations of the pond snail, Lymnaea stagnalis, to examine the effects of nitric oxide (NO) released from motoneurons innervating the esophagus on the feeding response. The present results suggest that first; even the low concentration of constitutive NO precisely regulates the feeding rhythm by suppressing high frequency feeding responses; second, that the high concentration of NO released after activation of the feeding central pattern generator following appetitive stimulation of the lips suppresses the feeding rate, resulting in recurrent inhibition. This is the first direct evidence that NO can function to suppress rhythmic activity in the brain. Copyright (C) 2000 Elsevier Science Ireland Ltd.
AB - Fictive feeding activity was monitored in the buccal ganglia of semi-intact preparations of the pond snail, Lymnaea stagnalis, to examine the effects of nitric oxide (NO) released from motoneurons innervating the esophagus on the feeding response. The present results suggest that first; even the low concentration of constitutive NO precisely regulates the feeding rhythm by suppressing high frequency feeding responses; second, that the high concentration of NO released after activation of the feeding central pattern generator following appetitive stimulation of the lips suppresses the feeding rate, resulting in recurrent inhibition. This is the first direct evidence that NO can function to suppress rhythmic activity in the brain. Copyright (C) 2000 Elsevier Science Ireland Ltd.
KW - Central pattern generator
KW - Cyclic guanosine monophosphate
KW - Feeding
KW - Lymnaea
KW - Nitric oxide
KW - Recurrent inhibition
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U2 - 10.1016/S0304-3940(00)01079-X
DO - 10.1016/S0304-3940(00)01079-X
M3 - Article
C2 - 10806323
AN - SCOPUS:0034685706
SN - 0304-3940
VL - 285
SP - 209
EP - 212
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -