NMDA induced glutamate release from the suprachiasmatic nucleus: An in vitro study in the rat

Toshiyuki Hamada, Rie Sonoda, Akihito Watanabe, Michiko Ono, Shigenobu Shibata, Shigenori Watanabe

研究成果: Article査読

16 被引用数 (Scopus)

抄録

The suprachiasmatic nucleus (SCN) has been identified as a pacemaker for mammalian circadian rhythms. Excitatory amino acid receptors, especially N- methyl-D-aspartate (NMDA) receptors, have been considered to play an important role in the transmission of light information from the retina to the circadian clocks in the SCN. In the present study, we showed that application of NMDA at circadian time (CT) 12-15 induced significant glutamate release from the SCN region in vitro. The NMDA-induced glutamate release was blocked by co-application of the NMDA receptor antagonist MK- 801, but not by that of tetrodotoxin. These results suggested that glutamate stimulated its own release by activating NMDA receptors. This NMDA-induced glutamate release through NMDA receptor-mediated mechanisms might be involved in NMDA-induced potent phase shifts.

本文言語English
ページ(範囲)93-96
ページ数4
ジャーナルNeuroscience Letters
256
2
DOI
出版ステータスPublished - 1998 11 6

ASJC Scopus subject areas

  • 神経科学(全般)

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