TY - JOUR
T1 - No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging
AU - Seki, Yasuhiro
AU - Aczel, Dora
AU - Torma, Ferenc
AU - Jokai, Matyas
AU - Boros, Anita
AU - Suzuki, Katsuhiko
AU - Higuchi, Mitsuru
AU - Tanisawa, Kumpei
AU - Boldogh, Istvan
AU - Horvath, Steve
AU - Radak, Zsolt
N1 - Funding Information:
ZR acknowledges support from the National Excellence Program (126823) and the Scientific Excellence Program, TKP2020-NKA-17, and TKP2021-EGA-37, at the Hungarian University of Sport Science, Innovation and Technology Ministry, Hungary.
Publisher Copyright:
© 2022, The Author(s).
PY - 2023
Y1 - 2023
N2 - Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging are strongly influenced by environmental and lifestyle factors, whether DNA methylation (DNAm) is affected by exercise training, remains unclear. In the present study, we investigated the relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, telomere length (TL) assessed by RT-PCR, DNA methylation-based estimation of TL (DNAmTL), and DNA methylation-based biomarkers of aging of master rowers (N = 146) and sedentary subjects (N = 95), aged between 37 and 85 years. It was found that the TL inversely correlated with chronological age. We could not detect an association between telomere length and VO2max, vertical jump, and working memory by RT-PCR method, while these physiological test results showed a correlation with DNAmTL. DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods. It appears that there are no strong beneficial effects of exercise or physiological fitness on telomere shortening, however, the degree of DNA methylation is associated with telomere length.
AB - Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging are strongly influenced by environmental and lifestyle factors, whether DNA methylation (DNAm) is affected by exercise training, remains unclear. In the present study, we investigated the relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, telomere length (TL) assessed by RT-PCR, DNA methylation-based estimation of TL (DNAmTL), and DNA methylation-based biomarkers of aging of master rowers (N = 146) and sedentary subjects (N = 95), aged between 37 and 85 years. It was found that the TL inversely correlated with chronological age. We could not detect an association between telomere length and VO2max, vertical jump, and working memory by RT-PCR method, while these physiological test results showed a correlation with DNAmTL. DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods. It appears that there are no strong beneficial effects of exercise or physiological fitness on telomere shortening, however, the degree of DNA methylation is associated with telomere length.
KW - DNA methylation
KW - Epigenetical aging
KW - Exercise
KW - Physical fitness
KW - Telomere
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U2 - 10.1007/s10522-022-10011-0
DO - 10.1007/s10522-022-10011-0
M3 - Article
AN - SCOPUS:85145321859
SN - 1389-5729
VL - 24
SP - 245
EP - 255
JO - Biogerontology
JF - Biogerontology
IS - 2
ER -