Non-enzymatic hydrolyses of aryl esters of thymidine 3'-monophosphate as probes for the rate-determining step in DNA hydrolysis.

N. Takeda*, Y. Okada, M. Yashiro, M. Komiyama

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

In order to shed light on the rate-limiting step in DNA hydrolysis, non-enzymatic hydrolyses of aryl esters of thymidine 3'-monophosphate have been kinetically examined. In alkaline solutions, these dinucleotide analogues were hydrolyzed far faster than was thymidylyl(3'-5')thymidine (TpT), indicating that the departure of the leaving group from the phosphorus atom is rate-limiting. The CeIV- and CeIV/PrIII combination-mediated hydrolyses of these analogues were also faster than the corresponding hydrolysis of the dinucleotide.

本文言語English
ページ(範囲)263-264
ページ数2
ジャーナルNucleic acids symposium series
37
出版ステータスPublished - 1997
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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