Non-invasive primate head restraint using thermoplastic masks

Caroline B. Drucker*, Monica L. Carlson, Koji Toda, Nicholas K. DeWind, Michael L. Platt

*この研究の対応する著者

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Background: The success of many neuroscientific studies depends upon adequate head fixation of awake, behaving animals. Typically, this is achieved by surgically affixing a head-restraint prosthesis to the skull. New method: Here we report the use of thermoplastic masks to non-invasively restrain monkeys' heads. Mesh thermoplastic sheets become pliable when heated and can then be molded to an individual monkey's head. After cooling, the custom mask retains this shape indefinitely for day-to-day use. Results: We successfully trained rhesus macaques (Macaca mulatta) to perform cognitive tasks while wearing thermoplastic masks. Using these masks, we achieved a level of head stability sufficient for high-resolution eye-tracking and intracranial electrophysiology. Comparison with existing method: Compared with traditional head-posts, we find that thermoplastic masks perform at least as well during infrared eye-tracking and single-neuron recordings, allow for clearer magnetic resonance image acquisition, enable freer placement of a transcranial magnetic stimulation coil, and impose lower financial and time costs on the lab. Conclusions: We conclude that thermoplastic masks are a viable non-invasive form of primate head restraint that enable a wide range of neuroscientific experiments.

本文言語English
ページ(範囲)90-100
ページ数11
ジャーナルJournal of Neuroscience Methods
253
DOI
出版ステータスPublished - 2015 9月 1
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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