Noradrenergic modulation of gonadotrophin-inhibitory hormone gene expression in the brain of Japanese quail

Y. Tobari*, N. Kansaku, Kazuyoshi Tsutsui

*この研究の対応する著者

    研究成果: Article査読

    6 被引用数 (Scopus)

    抄録

    Gonadotrophin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotrophin synthesis and release in birds and mammals. In Japanese quail, GnIH neurones express the noradrenergic receptor and receive noradrenergic innervation. Treatment with noradrenaline (NA) stimulates GnIH release from diencephalic tissue blocks in vitro. However, the effects of NA on hypothalamic GnIH gene expression have not been determined. We investigated noradrenergic regulation of GnIH gene expression in the brain of male quail using the selective noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4). We first showed that DSP-4 reduced the number of noradrenergic (dopamine-β-hydroxylase immunoreactive) cells in the locus coeruleus (LoC) and specifically lowered the NA concentration in the hypothalamus of male quail. Other monoamines, such as dopamine and serotonin, were not affected by drug treatment. DSP-4 did not decrease the numbers of noradrenergic cells of the lateral tegmental cell group, nor the plasma NA concentration. Decreased hypothalamic NA levels after DSP-4 treatment did not change GnIH gene expression in the brains of quail during their interaction with conspecifics. On the other hand, GnIH gene expression increased in the brains of quail socially isolated for 1 hour after DSP-4 treatment. These results suggest that some noradrenergic neurones have inhibitory effects on GnIH gene expression of the hypothalamus in solitary quail.

    本文言語English
    論文番号e12503
    ジャーナルJournal of Neuroendocrinology
    29
    8
    DOI
    出版ステータスPublished - 2017 8月 1

    ASJC Scopus subject areas

    • 内分泌学、糖尿病および代謝内科学
    • 内分泌学
    • 内分泌系および自律システム
    • 細胞および分子神経科学

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