Novel clusters of highly expressed genes accompany genomic amplification in breast cancers

Emi Ito, Reiko Honma, Yuka Yanagisawa, Jun ichi Imai, Sakura Azuma, Tetsunari Oyama, Susumu Ohwada, Tetsu Akiyama, Nobuo Nomura, Jun ichiro Inoue, Shinya Watanabe, Kentaro Semba

研究成果: Article

12 引用 (Scopus)

抜粋

Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.

元の言語English
ページ(範囲)3909-3914
ページ数6
ジャーナルFEBS Letters
581
発行部数21
DOI
出版物ステータスPublished - 2007 8 21

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Ito, E., Honma, R., Yanagisawa, Y., Imai, J. I., Azuma, S., Oyama, T., Ohwada, S., Akiyama, T., Nomura, N., Inoue, J. I., Watanabe, S., & Semba, K. (2007). Novel clusters of highly expressed genes accompany genomic amplification in breast cancers. FEBS Letters, 581(21), 3909-3914. https://doi.org/10.1016/j.febslet.2007.07.016