TY - JOUR
T1 - NRPSs and amide ligases producing homopoly(amino acid)s and homooligo(amino acid)s
AU - Hamano, Yoshimitsu
AU - Arai, Toshinobu
AU - Ashiuchi, Makoto
AU - Kino, Kuniki
PY - 2013
Y1 - 2013
N2 - Covering: 1943 to 2013 Microorganisms are capable of producing a wide variety of biopolymers. Homopoly(amino acid)s and homooligo(amino acid)s, which are made up of only a single type of amino acid, are relatively rare; in fact, only two homopoly(amino acid)s have been known to occur in nature: poly(ε-l-lysine) (ε-PL) and poly(γ-glutamic acid) (γ-PGA). Bacterial enzymes that produce homooligo(amino acid)s, such as l-β-lysine-, l-valine-, l-leucine-, l-isoleucine-, l-methionine-, and l-glutamic acid-oligopeptides and poly(α-l-glutamic acid) (α-PGA) have recently been identified, as well as ε-PL synthetase and γ-PGA synthetase. This article reviews the current knowledge about these unique enzymes producing homopoly(amino acid)s and homooligo(amino acid)s.
AB - Covering: 1943 to 2013 Microorganisms are capable of producing a wide variety of biopolymers. Homopoly(amino acid)s and homooligo(amino acid)s, which are made up of only a single type of amino acid, are relatively rare; in fact, only two homopoly(amino acid)s have been known to occur in nature: poly(ε-l-lysine) (ε-PL) and poly(γ-glutamic acid) (γ-PGA). Bacterial enzymes that produce homooligo(amino acid)s, such as l-β-lysine-, l-valine-, l-leucine-, l-isoleucine-, l-methionine-, and l-glutamic acid-oligopeptides and poly(α-l-glutamic acid) (α-PGA) have recently been identified, as well as ε-PL synthetase and γ-PGA synthetase. This article reviews the current knowledge about these unique enzymes producing homopoly(amino acid)s and homooligo(amino acid)s.
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U2 - 10.1039/c3np70025a
DO - 10.1039/c3np70025a
M3 - Review article
C2 - 23817633
AN - SCOPUS:84893162705
VL - 30
SP - 1087
EP - 1097
JO - Natural Product Reports
JF - Natural Product Reports
SN - 0265-0568
IS - 8
ER -