Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

Kazuhiko Uchida, Toshiro Morita, Takako Sato, Tsutomu Ogura, Rumiko Yamashita, Shigeru Noguchi, Hisanori Suzuki, Hiroshi Nyunoya, Masanao Miwa, Takashi Sugimura

研究成果: Article査読

108 被引用数 (Scopus)

抄録

The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted α-helix-turn-α-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3′ untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.

本文言語English
ページ(範囲)617-622
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
148
2
DOI
出版ステータスPublished - 1987 10 29
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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