Numerical analysis of blood flow distribution in 4- and 3-branch vascular grafts

Chikako Konoura, Takanobu Yagi, Masanori Nakamura, Kiyotaka Iwasaki, Yi Qian, Shigeo Okuda, Akihiro Yoshitake, Hideyuki Shimizu, Ryohei Yozu, Mitsuo Umezu

研究成果: Article

3 引用 (Scopus)

抄録

Trifurcated arch grafts (3-branch grafts) are now being used to repair the thoracic aorta in addition to conventional arch grafts (4-branch grafts). The anatomical shape of the 3-branch graft is different from the original vessel, so it is necessary for clinical application to evaluate blood flow distribution in the graft to assess whether there is adequate blood flow to the target organs. To achieve this, we developed a computational fluid dynamics (CFD) method to evaluate blood flow distribution in the grafts. Aortic blood flow was measured by phase-contrast magnetic resonance imaging (PC-MRI), and flow distribution into the branched vessels was obtained. The MRI image was used to create a patient-specific image model that represents the geometry of the aortic arch. The CFD analysis method was employed to determine a boundary condition of the blood flow analysis in the aorta using a patient-specific image model. We also created simplified models of 4-branch and 3-branch grafts and used our CFD analysis method to compare blood flow distribution among simplified models. It was found that blood flow distribution in the descending aorta was 71.3 % for the 4-branch graft and 67.7 % for the 3-branch graft, indicating that a sum of branching flow in the 3-branch graft was almost the same as the one in the 4-branch graft. Therefore, there is no major concern about implanting a new 3-branch graft. Our CFD analysis method may be applied to estimate blood flow distribution of a newly developed vascular graft prior to its clinical use and provide useful information for safe use of the graft.

元の言語English
ページ(範囲)157-163
ページ数7
ジャーナルJournal of Artificial Organs
16
発行部数2
DOI
出版物ステータスPublished - 2013 6

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Grafts
Blood Vessels
Numerical analysis
Blood
Transplants
Hydrodynamics
Computational fluid dynamics
Arches
Thoracic Aorta
Dynamic analysis
Magnetic resonance
Magnetic resonance imaging
Aorta
Repair
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine
  • Medicine (miscellaneous)

これを引用

Numerical analysis of blood flow distribution in 4- and 3-branch vascular grafts. / Konoura, Chikako; Yagi, Takanobu; Nakamura, Masanori; Iwasaki, Kiyotaka; Qian, Yi; Okuda, Shigeo; Yoshitake, Akihiro; Shimizu, Hideyuki; Yozu, Ryohei; Umezu, Mitsuo.

:: Journal of Artificial Organs, 巻 16, 番号 2, 06.2013, p. 157-163.

研究成果: Article

Konoura, C, Yagi, T, Nakamura, M, Iwasaki, K, Qian, Y, Okuda, S, Yoshitake, A, Shimizu, H, Yozu, R & Umezu, M 2013, 'Numerical analysis of blood flow distribution in 4- and 3-branch vascular grafts', Journal of Artificial Organs, 巻. 16, 番号 2, pp. 157-163. https://doi.org/10.1007/s10047-013-0694-4
Konoura, Chikako ; Yagi, Takanobu ; Nakamura, Masanori ; Iwasaki, Kiyotaka ; Qian, Yi ; Okuda, Shigeo ; Yoshitake, Akihiro ; Shimizu, Hideyuki ; Yozu, Ryohei ; Umezu, Mitsuo. / Numerical analysis of blood flow distribution in 4- and 3-branch vascular grafts. :: Journal of Artificial Organs. 2013 ; 巻 16, 番号 2. pp. 157-163.
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