Octopus gonadotrophin-releasing hormone: A multifunctional peptide in the endocrine and nervous systems of the cephalopod

H. Minakata*, S. Shigeno, N. Kano, S. Haraguchi, T. Osugi, Kazuyoshi Tsutsui

*この研究の対応する著者

    研究成果: Article査読

    44 被引用数 (Scopus)

    抄録

    The optic gland, which is analogous to the anterior pituitary in the context of gonadal maturation, is found on the upper posterior edge of the optic tract of the octopus Octopus vulgaris. In mature octopus, the optic glands enlarge and secrete a gonadotrophic hormone. A peptide with structural features similar to that of vertebrate gonadotophin-releasing hormone (GnRH) was isolated from the brain of octopus and was named oct-GnRH. Oct-GnRH showed luteinising hormone-releasing activity in the anterior pituitary cells of the Japanese quail Coturnix coturnix. Oct-GnRH immunoreactive signals were observed in the glandular cells of the mature optic gland. Oct-GnRH stimulated the synthesis and release of sex steroids from the ovary and testis, and elicited contractions of the oviduct. Oct-GnRH receptor was expressed in the gonads and accessory organs, such as the oviduct and oviducal gland. These results suggest that oct-GnRH induces the gonadal maturation and oviposition by regulating sex steroidogenesis and a series of egg-laying behaviours via the oct-GnRH receptor. The distribution and expression of oct-GnRH in the central and peripheral nervous systems suggest that oct-GnRH acts as a multifunctional modulatory factor in feeding, memory processing, sensory, movement and autonomic functions.

    本文言語English
    ページ(範囲)322-326
    ページ数5
    ジャーナルJournal of Neuroendocrinology
    21
    4
    DOI
    出版ステータスPublished - 2009

    ASJC Scopus subject areas

    • 内分泌学
    • 内分泌学、糖尿病および代謝内科学
    • 内分泌系および自律システム
    • 細胞および分子神経科学

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