On-chip cellomics technology for drug screening system using cardiomyocyte cells from human stem cell

Kenji Yasuda*

*この研究の対応する著者

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

Limitation of conventional human Ether-a-go-go Related Gene (hERG) assay and QT prolongation testing for accurate prediction of Torsades de Pointes (TdP) by compounds showed us the necessity of a new approach to evaluate global cardiac safety. As one of the advanced applications of an on-chip cellomics system, on-chip cardiomyocyte cell network-based re-entry model assay has the potential to measure the TdP probability as a pre-clinical test for cardiac safety. This system also can estimate the heart pressure, Na, K, and Ca ion channel conditions using a single cell-based optical/electrical measurement system. In this presentation, we present the system setup and then its possible application for drug discovery and toxicology.

本文言語English
ページ(範囲)545-557
ページ数13
ジャーナルYakugaku Zasshi
130
4
DOI
出版ステータスPublished - 2010 4
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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