On-chip integration of solid-phase-extraction and silicon pillar arrays for high efficient liquid chromatography

K. Nakanishi*, K. Shih, T. Kanamori, D. H. Yoon, T. Funatsu, M. Tsunoda, T. Sekiguchi, S. Shoji

*この研究の対応する著者

研究成果: Conference contribution

抄録

Silicon-based solid-phase-extraction (SPE) integrated liquid chromatography (LC) was proposed in this research. The integrated chip allowed continuous operation of selective sample enrichment and chromatography by a simple flow switching process. The sample reservoir was filled with extraction beads after silicon chip fabrication, and then targets were selectively adsorbed onto the beads. Pillar arrays provided uniform and dense sample band, while the targets were released from the beads. The integrated chip achieved more than 160 times higher fluorescence intensity of samples compared to normal injection chips, and coumarin 525 and 545 were successfully separated in 30-mm-long LC channel within 1 min.

本文言語English
ホスト出版物のタイトルMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
出版社Chemical and Biological Microsystems Society
ページ1936-1938
ページ数3
ISBN(電子版)9780979806483
出版ステータスPublished - 2015
イベント19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
継続期間: 2015 10 252015 10 29

出版物シリーズ

名前MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
国/地域Korea, Republic of
CityGyeongju
Period15/10/2515/10/29

ASJC Scopus subject areas

  • 制御およびシステム工学

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