On-chip pre-clinical cardiac toxicity: Testing compounds beyond herg and qt using hES/hiPS cardiomyocyte re-entry cell network model on a chip

K. Yasuda, T. Kaneko, F. Nomura

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

Limitation of conventional hERG assay and QT prolongation testing for accurate prediction of Torsades de Pointes (TdP) by compounds unvailed us the necesity of new approach to evaluate global cardiac safety. On-chip re-entry cell network model assay has the potential to measure the TdP probability as pre-clinical testing for cardiac safety by the single cell-based optical/electrical measurement of the heart pressure, Na, K, Ca ion channel conditions and their fluctuations. The application of ion channel inhibitors resulted in dose-dependent changes to the field potential waveform, and these changes were identical to those induced in the native cardiomyocytes. This study shows that on-chip model represent a promising in vitro assay for cardiac toxicity and drug screening.

本文言語English
ホスト出版物のタイトル14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
ページ716-718
ページ数3
出版ステータスPublished - 2010 12 1
外部発表はい
イベント14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
継続期間: 2010 10 32010 10 7

出版物シリーズ

名前14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
2

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

ASJC Scopus subject areas

  • Control and Systems Engineering

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