On the mechanical blood trauma: Effect of turbulence

M. V. Kameneva, G. W. Burgreen, K. Kono, J. F. Antaki, B. M. Repko, M. Umezu

研究成果: Conference contribution

3 被引用数 (Scopus)

抄録

Mechanical blood trauma is still one of the major obstacles in the development of cardiovascular devices. The mechanisms of this blood damage are heterogeneous and are not completely identified. Experimental and computational studies were performed to elucidate the role of turbulent stresses in hemolysis. For the experimental study suspensions of bovine red blood cells (RBCs) in saline or in dextran solution were driven through a closed circulating loop by a centrifugal pump. A small capillary tube with the inner diameter of 1 mm and the length of 50 mm was incorporated into loop with tapered connectors. It was shown that, at the same wall shear stress, the level of hemolysis is significantly higher under turbulent flow conditions than laminar flow conditions. This demonstrated that turbulent stresses contribute strongly to blood trauma. These results concurred with predicted hemolysis by computational fluid dynamics (CFD) modeling of the same blood flow conditions.

本文言語English
ホスト出版物のタイトルAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
出版社IEEE
ページ数1
ISBN(印刷版)0780356756
出版ステータスPublished - 1999 12 1
外部発表はい
イベントProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
継続期間: 1999 10 131999 10 16

出版物シリーズ

名前Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
2
ISSN(印刷版)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period99/10/1399/10/16

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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