One-step synthesis of ethyl quinaldates by lewis acid catalyzed three-component coupling reaction of aromatic amines, aliphatic aldehydes and ethyl glyoxylate

Takashi Inada*, Takayuki Nakajima, Isao Shimizu

*この研究の対応する著者

研究成果査読

15 被引用数 (Scopus)

抄録

A convenient, efficient and simple one-pot method for the synthesis of quinaldates was developed by three-component coupling reaction of an arylamine (1), ethyl glyoxylate and an aliphatic aldehyde (2) in the presence of Lewis acid catalyst. The reaction proceeded most effectively using Yb(OTf)3 as a catalyst.

本文言語English
ページ(範囲)611-619
ページ数9
ジャーナルHeterocycles
66
1
DOI
出版ステータスPublished - 2005 12 31

ASJC Scopus subject areas

  • 有機化学

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