One-step synthesis of ethyl quinaldates by lewis acid catalyzed three-component coupling reaction of aromatic amines, aliphatic aldehydes and ethyl glyoxylate

Takashi Inada; Takayuki Nakajima; Isao Shimizu

doi:10.3987/COM-05-S(K)48

One-step synthesis of ethyl quinaldates by lewis acid catalyzed three-component coupling reaction of aromatic amines, aliphatic aldehydes and ethyl glyoxylate

Takashi Inada^*, Takayuki Nakajima, Isao Shimizu

^*この研究の対応する著者

早稲田大学

研究成果: Article › 査読

15 被引用数 (Scopus)

抄録

A convenient, efficient and simple one-pot method for the synthesis of quinaldates was developed by three-component coupling reaction of an arylamine (1), ethyl glyoxylate and an aliphatic aldehyde (2) in the presence of Lewis acid catalyst. The reaction proceeded most effectively using Yb(OTf)₃ as a catalyst.

本文言語	English
ページ（範囲）	611-619
ページ数	9
ジャーナル	Heterocycles
巻	66
号	1
DOI	https://doi.org/10.3987/COM-05-S(K)48
出版ステータス	Published - 2005 12月 31

ASJC Scopus subject areas

有機化学

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10.3987/COM-05-S(K)48

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引用スタイル

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abstract = "A convenient, efficient and simple one-pot method for the synthesis of quinaldates was developed by three-component coupling reaction of an arylamine (1), ethyl glyoxylate and an aliphatic aldehyde (2) in the presence of Lewis acid catalyst. The reaction proceeded most effectively using Yb(OTf)3 as a catalyst.",

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AB - A convenient, efficient and simple one-pot method for the synthesis of quinaldates was developed by three-component coupling reaction of an arylamine (1), ethyl glyoxylate and an aliphatic aldehyde (2) in the presence of Lewis acid catalyst. The reaction proceeded most effectively using Yb(OTf)3 as a catalyst.

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