Optic nerve stimulation-induced increase of release of 3h-glutamate and 3h-aspartate but not 3h-gaba from the suprachiasmatic nucleus in slices of rat hypothalamus

Shyh Yuh Liou, Shigenobu Shibata, Katsunori Iwasaki, Showa Ueki

研究成果: Article査読

155 被引用数 (Scopus)


This study investigates the possibility of glutamate and/or aspartate as an excitatory transmitter in the retinohypothalamic fibers' terminal within the anterior hypothalamus, including the suprachiasmatic nucleus (SCN). We studied the release of [3]H-Glu and 3H-Asp from the SCN of rat hypothalamic slices produced by optic nerve stimulation. Stimulation of the optic nerve released 3H-Glu, 3H-Asp but not 3H-GABA, while stimulation of the SCN released all three. These releases were suppressed in both Ca2+ free Krebs and tetrodotoxin (TTX) 1 μM containing Krebs. The present result with previous electrophysiological observations strongly suggest that glutamate and/or aspartate are included in this retinohypothalamic termination, while GABA is included in intrinsic and/or extrinsic neurons of the SCN, excluding the terminal of the retinohypothalamic fibers.

ジャーナルBrain Research Bulletin
出版ステータスPublished - 1986 4

ASJC Scopus subject areas

  • Neuroscience(all)

フィンガープリント 「Optic nerve stimulation-induced increase of release of <sup>3</sup>h-glutamate and <sup>3</sup>h-aspartate but not <sup>3</sup>h-gaba from the suprachiasmatic nucleus in slices of rat hypothalamus」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。