Organosilane self-assembled monolayer-modified field effect transistors for on-chip ion and biomolecule sensing

Daisuke Niwa; Kaoru Omichi; Norikazu Motohashi; Takayuki Homma; Tetsuya Osaka

doi:10.1016/j.snb.2004.11.055

Organosilane self-assembled monolayer-modified field effect transistors for on-chip ion and biomolecule sensing

Daisuke Niwa, Kaoru Omichi, Norikazu Motohashi, Takayuki Homma, Tetsuya Osaka

研究成果: Article

42 被引用数 (Scopus)

抄録

Field effect transistors (FETs) modified with various functional monolayers, such as organosilane monolayer, were formed on the identical substrate by precise control of the fabrication processes. The devices showed a typical transistor property with a good stability in aqueous solutions. The amino monolayer-modified FET acted as an ion sensitive FET with a good pH sensitivity of 58 mV/pH, and the perfluoro-alkyl monolayer-modified FET worked as a reference device. Moreover, the device with enzyme immobilized onto amino modified gate electrode enabled to detect trace concentration (10^-9 to 10^-6 M) of urea with a high sensitivity of 64 mV/decade. These monolayer-modified devices were expected to be applied as working and reference electrodes for on-chip ion and biosensing.

本文言語	English
ページ（範囲）	721-726
ページ数	6
ジャーナル	Sensors and Actuators, B: Chemical
巻	108
号	1-2 SPEC. ISS.
DOI	https://doi.org/10.1016/j.snb.2004.11.055
出版ステータス	Published - 2005 7 22

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/j.snb.2004.11.055

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引用スタイル

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abstract = "Field effect transistors (FETs) modified with various functional monolayers, such as organosilane monolayer, were formed on the identical substrate by precise control of the fabrication processes. The devices showed a typical transistor property with a good stability in aqueous solutions. The amino monolayer-modified FET acted as an ion sensitive FET with a good pH sensitivity of 58 mV/pH, and the perfluoro-alkyl monolayer-modified FET worked as a reference device. Moreover, the device with enzyme immobilized onto amino modified gate electrode enabled to detect trace concentration (10-9 to 10-6 M) of urea with a high sensitivity of 64 mV/decade. These monolayer-modified devices were expected to be applied as working and reference electrodes for on-chip ion and biosensing.",

keywords = "Field effect transistor, Ion and biomolecule detection, On-chip biosensing device, Reference device, Self-assembled monolayer",

author = "Daisuke Niwa and Kaoru Omichi and Norikazu Motohashi and Takayuki Homma and Tetsuya Osaka",

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AU - Niwa, Daisuke

AU - Omichi, Kaoru

AU - Motohashi, Norikazu

AU - Homma, Takayuki

AU - Osaka, Tetsuya

PY - 2005/7/22

Y1 - 2005/7/22

N2 - Field effect transistors (FETs) modified with various functional monolayers, such as organosilane monolayer, were formed on the identical substrate by precise control of the fabrication processes. The devices showed a typical transistor property with a good stability in aqueous solutions. The amino monolayer-modified FET acted as an ion sensitive FET with a good pH sensitivity of 58 mV/pH, and the perfluoro-alkyl monolayer-modified FET worked as a reference device. Moreover, the device with enzyme immobilized onto amino modified gate electrode enabled to detect trace concentration (10-9 to 10-6 M) of urea with a high sensitivity of 64 mV/decade. These monolayer-modified devices were expected to be applied as working and reference electrodes for on-chip ion and biosensing.

AB - Field effect transistors (FETs) modified with various functional monolayers, such as organosilane monolayer, were formed on the identical substrate by precise control of the fabrication processes. The devices showed a typical transistor property with a good stability in aqueous solutions. The amino monolayer-modified FET acted as an ion sensitive FET with a good pH sensitivity of 58 mV/pH, and the perfluoro-alkyl monolayer-modified FET worked as a reference device. Moreover, the device with enzyme immobilized onto amino modified gate electrode enabled to detect trace concentration (10-9 to 10-6 M) of urea with a high sensitivity of 64 mV/decade. These monolayer-modified devices were expected to be applied as working and reference electrodes for on-chip ion and biosensing.

KW - Field effect transistor

KW - Ion and biomolecule detection

KW - On-chip biosensing device

KW - Reference device

KW - Self-assembled monolayer

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