Oscillator for self-assembled DNA nanomachines

Masahiro Takinoue*, Daisuke Kiga, Koh Ichiroh Shohda, Akira Suyama

*この研究の対応する著者

研究成果査読

抄録

Self-assembled DNA nanomachines have been energetically developed recently. We have invented an RNA-oscillator constructed with an autonomous biomolecular computing system in order to operate periodically DNA nanomachines driven by DNA/RNA hybridization. The biomolecular computing system, which we have developed, can convert RNA sequences from input strand to output strand by nucleic-acids hybridizations and enzymatic reactions at a constant temperature. A feedback network of the autonomous biomolecular computing system can oscillate. In this study, we simulated behaviors of the oscillator before in vitro experiments by describing each reaction step using simultaneous nonlinear differential equations. As the result of numerical simulation, we found that there were some conditions on which RNA concentrations could oscillate and the conditions depended on the balance between RNA production and degradation rates.

本文言語English
ページ104-106
ページ数3
出版ステータスPublished - 2007 12 1
外部発表はい
イベント4th Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2007 - Snowbird, UT, United States
継続期間: 2007 4 182007 4 21

Other

Other4th Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2007
国/地域United States
CitySnowbird, UT
Period07/4/1807/4/21

ASJC Scopus subject areas

  • ハードウェアとアーキテクチャ
  • 電子工学および電気工学

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