抄録
We examined the effect of increased plasma osmolality (P(osm)) on cutaneous vasodilatory response to increased esophageal temperature (T(es)) in passively heated human subjects (n = 6). To modify P(osm), subjects were infused with 0.9, 2, or 3% NaCl infusions (Inf) for 90 min on separate days. Infusion rates were 0.2, 0.15, and 0.125 ml-min--1·kg body wt-1 for 0.9, 2, and 3% Inf, respectively, which produced relatively similar plasma volume expansion. Thirty minutes after the end of infusion, subjects immersed their lower legs in a water bath at 42°C (room temperature 28°C) for 60 min after 10 min of preheating control measurements. Passive heating without infusion (NI) served as time control to account for the effect of volume expansion. P(osm) (mosmol/kgH2O) values at the onset of passive heating were 289.9 ± 1.4, 292.1 ± 0.6, 298.7 ± 0.7, and 305.6 ± 0.6 after NI, 0.9% Inf, 2% Inf, and 8% Inf, respectively. The increases in T(es) (ΔT(es)) at equilibrium during passive heating (mean ΔT(es) during 55-60 min)were 0.47 ± 0.08, 0.59 ± 0.08, 0.85 ± 0.13, and 1.09 ± 0.12°C after NI, 0.9% Inf, 2% Inf, and 3% Inf, respectively, which indicates that T(es) at equilibrium increased linearly as P(osm) increased. ΔT(es) required to elicit cutaneous vasodilation (ΔT(es) threshold for cutaneous vasodilation) also increased linearly as P(osm) increased as well as the ΔT(es) threshold for sweating. The calculated increases in these thresholds per unit rise in P(osm) from regression analysis were 0.044°C for the cutaneous vasodilation and 0.034°C for sweating. Thus the ΔT(es) thresholds for cutaneous vasodilation and sweating are shifted to higher ΔT(es) along with the increase in P(osm), and these shifts resulted in the higher increase in T(es) during passive heating.
| 元の言語 | English |
|---|---|
| ジャーナル | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| 巻 | 273 |
| 発行部数 | 1 42-1 |
| 出版物ステータス | Published - 1997 7 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Physiology
- Physiology (medical)
これを引用
Osmoregulatory inhibition of thermally induced cutaneous vasodilation in passively heated humans. / Takamata, Akira; Nagashima, Kei; Nose, Hiroshi; Morimoto, Taketoshi.
：: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 巻 273, 番号 1 42-1, 07.1997.研究成果: Article
}
TY - JOUR
T1 - Osmoregulatory inhibition of thermally induced cutaneous vasodilation in passively heated humans
AU - Takamata, Akira
AU - Nagashima, Kei
AU - Nose, Hiroshi
AU - Morimoto, Taketoshi
PY - 1997/7
Y1 - 1997/7
N2 - We examined the effect of increased plasma osmolality (P(osm)) on cutaneous vasodilatory response to increased esophageal temperature (T(es)) in passively heated human subjects (n = 6). To modify P(osm), subjects were infused with 0.9, 2, or 3% NaCl infusions (Inf) for 90 min on separate days. Infusion rates were 0.2, 0.15, and 0.125 ml-min--1·kg body wt-1 for 0.9, 2, and 3% Inf, respectively, which produced relatively similar plasma volume expansion. Thirty minutes after the end of infusion, subjects immersed their lower legs in a water bath at 42°C (room temperature 28°C) for 60 min after 10 min of preheating control measurements. Passive heating without infusion (NI) served as time control to account for the effect of volume expansion. P(osm) (mosmol/kgH2O) values at the onset of passive heating were 289.9 ± 1.4, 292.1 ± 0.6, 298.7 ± 0.7, and 305.6 ± 0.6 after NI, 0.9% Inf, 2% Inf, and 8% Inf, respectively. The increases in T(es) (ΔT(es)) at equilibrium during passive heating (mean ΔT(es) during 55-60 min)were 0.47 ± 0.08, 0.59 ± 0.08, 0.85 ± 0.13, and 1.09 ± 0.12°C after NI, 0.9% Inf, 2% Inf, and 3% Inf, respectively, which indicates that T(es) at equilibrium increased linearly as P(osm) increased. ΔT(es) required to elicit cutaneous vasodilation (ΔT(es) threshold for cutaneous vasodilation) also increased linearly as P(osm) increased as well as the ΔT(es) threshold for sweating. The calculated increases in these thresholds per unit rise in P(osm) from regression analysis were 0.044°C for the cutaneous vasodilation and 0.034°C for sweating. Thus the ΔT(es) thresholds for cutaneous vasodilation and sweating are shifted to higher ΔT(es) along with the increase in P(osm), and these shifts resulted in the higher increase in T(es) during passive heating.
AB - We examined the effect of increased plasma osmolality (P(osm)) on cutaneous vasodilatory response to increased esophageal temperature (T(es)) in passively heated human subjects (n = 6). To modify P(osm), subjects were infused with 0.9, 2, or 3% NaCl infusions (Inf) for 90 min on separate days. Infusion rates were 0.2, 0.15, and 0.125 ml-min--1·kg body wt-1 for 0.9, 2, and 3% Inf, respectively, which produced relatively similar plasma volume expansion. Thirty minutes after the end of infusion, subjects immersed their lower legs in a water bath at 42°C (room temperature 28°C) for 60 min after 10 min of preheating control measurements. Passive heating without infusion (NI) served as time control to account for the effect of volume expansion. P(osm) (mosmol/kgH2O) values at the onset of passive heating were 289.9 ± 1.4, 292.1 ± 0.6, 298.7 ± 0.7, and 305.6 ± 0.6 after NI, 0.9% Inf, 2% Inf, and 8% Inf, respectively. The increases in T(es) (ΔT(es)) at equilibrium during passive heating (mean ΔT(es) during 55-60 min)were 0.47 ± 0.08, 0.59 ± 0.08, 0.85 ± 0.13, and 1.09 ± 0.12°C after NI, 0.9% Inf, 2% Inf, and 3% Inf, respectively, which indicates that T(es) at equilibrium increased linearly as P(osm) increased. ΔT(es) required to elicit cutaneous vasodilation (ΔT(es) threshold for cutaneous vasodilation) also increased linearly as P(osm) increased as well as the ΔT(es) threshold for sweating. The calculated increases in these thresholds per unit rise in P(osm) from regression analysis were 0.044°C for the cutaneous vasodilation and 0.034°C for sweating. Thus the ΔT(es) thresholds for cutaneous vasodilation and sweating are shifted to higher ΔT(es) along with the increase in P(osm), and these shifts resulted in the higher increase in T(es) during passive heating.
KW - Body core temperature threshold
KW - Osmoregulation
KW - Plasma osmolality
KW - Skin blood flow
KW - Sweating
KW - Thermoregulation
UR - http://www.scopus.com/inward/record.url?scp=0030739490&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030739490&partnerID=8YFLogxK
M3 - Article
C2 - 9249550
AN - SCOPUS:0030739490
VL - 273
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0193-1849
IS - 1 42-1
ER -