Outcome After Radiosurgery for Brain Metastases in Patients With Low Karnofsky Performance Scale (KPS) Scores

Mikhail F. Chernov*, Kotaro Nakaya, Masahiro Izawa, Motohiro Hayashi, Yuki Usuba, Koichi Kato, Yoshihiro Muragaki, Hiroshi Iseki, Tomokatsu Hori, Kintomo Takakura

*この研究の対応する著者

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Purpose: The objective of this retrospective study was evaluation of the outcome after stereotactic radiosurgery (SRS) in patients with intracranial metastases and poor performance status. Methods and Materials: Forty consecutive patients with metastatic brain tumors and Karnofsky performance scale (KPS) scores ≤50 (mean, 43 ± 8; median, 40) treated with SRS were analyzed. Poor performance status was caused by presence of intracranial metastases in 28 cases (70%) and resulted from uncontrolled extracerebral disease in 12 (30%). Results: Survival after SRS varied from 3 days to 11.5 months (mean, 3.8 ± 2.9 months; median, 3.3 months). Survival probability constituted 0.50 ± 0.07 at 3 months and 0.20 ± 0.05 at 6 months posttreatment. Cause of low KPS score (p = 0.0173) and presence of distant metastases beside the brain (p = 0.0308) showed statistically significant associations with overall survival in multivariate Cox proportional hazards regression analysis. Median survival was 6.0 months if low KPS score was caused by cerebral disease and distant metastases in regions beyond the brain were absent, 3.3 months if low KPS score was caused by cerebral disease and distant metastases in regions beyond the brain were present, and 1.0 month if poor performance status resulted from extracerebral disease. Conclusions: Identification of the cause of low KPS score (cerebral vs. extracerebral) in patients with metastatic brain tumor(s) may be important for prediction of the outcome after radiosurgical treatment. If poor patient performance status without surgical indications is caused by intracranial tumor(s), SRS may be a reasonable treatment option.

本文言語English
ページ(範囲)1492-1498
ページ数7
ジャーナルInternational Journal of Radiation Oncology Biology Physics
67
5
DOI
出版ステータスPublished - 2007 4月 1
外部発表はい

ASJC Scopus subject areas

  • 放射線
  • 腫瘍学
  • 放射線学、核医学およびイメージング
  • 癌研究

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