Oxygen- and carbon monoxide-binding kinetic parameters for liposomal heme under semi-physiological condition

Eishun Tsuchida*, Hiroyuki Nishide, Mikiya Sekine, Makoto Yuasa, Tetsutaro Iizuka, Yuzuru Ishimura

*この研究の対応する著者

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Binding and dissociation rate constants of oxygen and carbon monoxide with the meso-tetra(α,α,α,α-(o-pivalamidophenyl))porphinato iron-mono(1-lauryl-2-methylimidazole) complex incorporated into the liposomes of dimyristoylphosphatidylcholine (liposomal heme) were measured with flash-photolysis method at pH 7.0 and 20 °C. Extra large quantum yield was observed for the photo-dissociation of the oxygen adduct, while that for the CO adduct was relatively small. Rate constants for the binding and the dissociation were comparable to those of hemoglobin except for the oxygen-binding rate constant.

本文言語English
ページ(範囲)858-863
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
109
3
DOI
出版ステータスPublished - 1982 12 15

ASJC Scopus subject areas

  • 生化学
  • 生物理学
  • 分子生物学

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