An oxygen-supplying medium (OSM), which was prepared by embedding a synthetic heme complex in a bilayer of polymerized lipid liposome (polylipid liposome/heme), could blind molecular oxygen reversibly under physiological conditions. The oxygen-exchange reaction of OSM with blood was examined by using a liquid/liquid artificial lung device. For example, deoxy-blood (p//S(O//2) equals 0 torr) was passed countercurrent to oxy-OSM (p//S(O//2) equals 154 torr) through hollow fibers of the device to provide oxy-blood (p//b(O//2) equals 57 torr). The OSM was physicochemically and mechanically stable under strong shear stress during the passage through the hollow fibers and acted as the oxygen mediator to blood.
|ジャーナル||Journal of macromolecular science. Chemistry|
|出版ステータス||Published - 1987|
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