Oxygen ion implantation at 20 to 2000 keV into polysulfone for improvement of endothelial cell adhesion

Guochun Xu*, Yutaka Hibino, Yasuo Suzuki, Yoshiaki Suzuki, Kimi Kurotobi, Minoru Osada, Masaya Iwaki, Makoto Kaibara, Masao Tanihara, Yukio Imanishi


研究成果: Article査読

6 被引用数 (Scopus)


The irradiation effects of oxygen on polysulfone have been investigated at energies of 20 keV, 150 keV and 2 MeV. The strong improvement of endothelial cell adhesion and proliferation is found on ion irradiated polysulfone at 20 keV. Such improvement is declined with increasing ion energy. The changes of surface color and free energy are strongly dependent on ion energy and dose. The formation of amorphous carbon phase is demonstrated by Raman spectroscopy and its degree is correspondent to the color changes observed. The formations of hydroxyl and carboxyl groups are confirmed by the attenuated total reflectance (ATR) FTIR spectroscopy. The depletions of heteroatoms are conjectured by detail analysis of X-ray photoelectron spectroscopy (XPS). Since no single one of these changes can be related directly to the improved adhesion and proliferation of endothelial cells on irradiated surface, we argue that the distribution of functional groups is crucial in promoting the adhesion of endothelial cells. Although the distribution cannot directly be detected at present, the irradiation effects were related to the results of TRIM simulation. The surface changes can be controlled by adjusting the size energy and dose of irradiating ion for the optimum morphology to cell adhesion. (C) 2000 Elsevier Science B.V.

ジャーナルColloids and Surfaces B: Biointerfaces
出版ステータスPublished - 2000 12月 30

ASJC Scopus subject areas

  • バイオテクノロジー
  • コロイド化学および表面化学
  • 物理化学および理論化学
  • 表面および界面


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