Oxygen permeability of biodegradable copolycaprolactones

Shenguo Wang, Hiroyuki Nishide, Eishun Tsuchida*

*この研究の対応する著者

研究成果査読

10 被引用数 (Scopus)

抄録

Polycaprolactone is one of the biodegradable polymers with good drug permeability. In the present paper, polycaprolactone and three kinds of copolycaprolactone-polycaprolactone-poly(ethylene oxide)-polycaprolactone triblock copolymer (PCE), polycaprolactone/polycaprolactone-poly(ethylene oxide)/polylactide tricomponents random block copolymer (PCEL) and polycaprolactone/ poly(ethylene terephthalate) random block copolymer (PETCL)-were synthesized. The biodegradation behavior of these polymers were shown by degradation tests in vitro, ex vivo and in vivo. The oxygen permeabilities of these polymers were in the range of 10-10 ∼ 10-9 cm3 (STP) cm/cm2 sec cm Hg. Copolymers PCE and PCEL displayed O2 and N2 permeability coefficients (PO2/PN2) ratios of about 9. The effects of composition and crystallinity of the copolymers on biodegradability and the oxygen permeability of the polymer were discussed.

本文言語English
ページ(範囲)282-286
ページ数5
ジャーナルPolymers for Advanced Technologies
10
5
出版ステータスPublished - 1999 5

ASJC Scopus subject areas

  • ポリマーおよびプラスチック

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