Oxygen-transport and solution properties of polylipid/Hb vesicles (ARC)

Shinji Takeoka, E. Hasegawa, Hiroyuki Nishide, E. Tsuchida, S. Sekiguchi

研究成果: Article

5 引用 (Scopus)

抄録

Polymerized phospholipid vesicle encapsulating Hb (polylipid/Hb vesicle) was prepared from a mixture of unsaturated phospholipid, cholesterol and unsaturated fatty acid and polymerization by γ-ray irradiation. The average radius of resulting vesicles was 203 ± 39 nm and concentrated Hb (30 wt%) was efficiently encapsulated. γ-Ray polymerization proceeds theoretically at low temperature (4 °C). P50 and oxygen transporting efficiency were adjusted to 40 mmHg and 40%, respectively. Oncotic pressure and solution viscosity can be controlled to the same values as blood.

元の言語English
ページ(範囲)399-404
ページ数6
ジャーナルBiomaterials, Artificial Cells, and Immobilization Biotechnology
20
発行部数2-4
出版物ステータスPublished - 1992

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AIDS-Related Complex
Phospholipids
Polymerization
Oxygen
Unsaturated fatty acids
Cholesterol
Unsaturated Fatty Acids
Viscosity
Blood
Irradiation
Pressure
Temperature

ASJC Scopus subject areas

  • Medicine(all)

これを引用

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T1 - Oxygen-transport and solution properties of polylipid/Hb vesicles (ARC)

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AU - Hasegawa, E.

AU - Nishide, Hiroyuki

AU - Tsuchida, E.

AU - Sekiguchi, S.

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AB - Polymerized phospholipid vesicle encapsulating Hb (polylipid/Hb vesicle) was prepared from a mixture of unsaturated phospholipid, cholesterol and unsaturated fatty acid and polymerization by γ-ray irradiation. The average radius of resulting vesicles was 203 ± 39 nm and concentrated Hb (30 wt%) was efficiently encapsulated. γ-Ray polymerization proceeds theoretically at low temperature (4 °C). P50 and oxygen transporting efficiency were adjusted to 40 mmHg and 40%, respectively. Oncotic pressure and solution viscosity can be controlled to the same values as blood.

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