Polymerized phospholipid vesicle encapsulating Hb (polylipid/Hb vesicle) was prepared from a mixture of unsaturated phospholipid, cholesterol and unsaturated fatty acid and polymerization by y-ray irradiation. The average radius of resulting vesicles was 203 39 nm and concentrated Hb (30 wt%) was efficiently encapsulated. y-Ray polymerization proceeds theoretically at low temperature (4C). Pso and oxygen transporting efficiency were adjusted to 40 mmHg and 40%, respectively. Oncotic pressure and solution viscosity can be controlled to the same values as blood.
|ジャーナル||Biomaterials, Artificial Cells and Immobilization Biotechnology|
|出版ステータス||Published - 1992 1|
ASJC Scopus subject areas