Oxygen-transport and solution properties of polylipid/hb vesicles (arc)

Shinji Takeoka, Etsuo Hasegawa, Hiroyuki Nishide, Eishun Tsuchida, Sadayoshi Sekiguchi

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Polymerized phospholipid vesicle encapsulating Hb (polylipid/Hb vesicle) was prepared from a mixture of unsaturated phospholipid, cholesterol and unsaturated fatty acid and polymerization by y-ray irradiation. The average radius of resulting vesicles was 203 39 nm and concentrated Hb (30 wt%) was efficiently encapsulated. y-Ray polymerization proceeds theoretically at low temperature (4C). Pso and oxygen transporting efficiency were adjusted to 40 mmHg and 40%, respectively. Oncotic pressure and solution viscosity can be controlled to the same values as blood.

本文言語English
ページ(範囲)399-404
ページ数6
ジャーナルBiomaterials, Artificial Cells and Immobilization Biotechnology
20
4 --Feb
DOI
出版ステータスPublished - 1992 1

ASJC Scopus subject areas

  • Medicine(all)

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